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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100ug(solution) | ¥2500.00 | 现货 | |
1mg(solution) | ¥8500.00 | 现货 |
特色产品
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- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Concanamycin A是液泡型ATP酶(V-ATP酶)的特异性抑制剂,IC50值为10 nM [1]。
液泡型ATP酶(V-ATP酶)在透明细胞中表达,可以酸化附睾的内腔,这对于男性生育能力是必不可少的。更重要的是,它可以引起质子在细胞外基质的积累,这对于在酸性微环境中维持细胞内pH具有重要作用。有报道称,在几种恶性肿瘤中,V-ATP酶参与酸化实体瘤周围的微环境及诱导肿瘤浸润/多药耐药性 [2]。
Concanamycin A(CMA)是特异性的V-ATP酶抑制剂,与之前报道的V-ATP酶抑制剂SS33410不同。在口腔鳞状细胞癌(OSCC)细胞系(MRSK81-5、SAS和HSC-4)中,低浓度CMA诱导肿瘤细胞的凋亡 [3]。使用concanamycin A预处理结直肠癌细胞系可以通过阻断V-ATP酶诱导的内含体酸化,显著增强肿瘤坏死因子(TNF)相关凋亡诱导配体(TRAIL)诱导的细胞凋亡 [4]。Concanamycin A通过抑制前列腺癌细胞系C4-2B细胞中的V-ATP酶,可以减少80%肿瘤浸润 [5]。
研究表明,Concanamycin A 通过穿孔素介导的细胞毒性途径,可以有效抑制CTL细胞毒性 [6]。
参考文献:
[1].Huss, M., et al., Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem, 2002. 277(43): p. 40544-8.
[2].Muroi, M., et al., Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus. Cell Struct Funct, 1993. 18(3): p. 139-49.
[3].Kiyoshima, T., et al., Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS One, 2013. 8(11).
[4]. Horova V, et al., Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes. FEBS J, 2013. 280(14).
[5]. Michel V, et al., Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion. Int J Cancer. 2013.132(2).
[6]. Benkhoucha M et al., The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity. J Neuroinflammation. 2013, 10.
产品性质
物理外观 | A solution in acetonitrile. To change the solvent, simply evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice. |
CAS号 | 80890-47-7 |
分子式 | C46H75NO14 |
分子量 | 866.09 |
溶解度 | Limited solubility, soluble in DMSO |
SMILES | CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Pengwei Wang, et al. "Exo84c-regulated degradation is involved in the normal self-incompatible response in Brassicaceae." Cell Rep. 2024 Mar 26;43(3):113913. PMID: 38442016
- 2. Ling-Yan Wang, Jian Li, et al. "Orosomucoid proteins limit endoplasmic reticulum stress in plants." New Phytol. 2023 Aug 22. PMID: 37606093
- 3. Du-Hwa Lee, Ilyeong Choi, et al. "Three consecutive cytosolic glycolysis enzymes modulate autophagic flux." Plant Physiol. 2023 Aug 4;kiad439. PMID: 37539947
- 4. Chen Wan, Hui Zhang, et al. "Selective autophagy regulates chloroplast protein import and promotes plant stress tolerance." EMBO J. 2023 Jul 17;42(14):e112534. PMID: 37248861
- 5. Ye Chen, Xiao Wu, et al. "Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance." EMBO Rep. 2022 Feb 3;23(3):e53373. PMID: 34994492
- 6. Zhang G, Xu M, et al. "Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells." Toxicol Appl Pharmacol. 2016 Dec 15;313:1-9. PMID: 27742270