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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥727.00 | 现货 | |
10mg | ¥1272.00 | 现货 | |
25mg | ¥2545.00 | 现货 | |
50mg | ¥3818.00 | 现货 |
特色产品
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- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Nigericin sodium salt是一种离子载体,交换K+和H+穿过生物膜。
离子载体是一种脂溶性分子,运输离子穿过细胞膜。
在含Na+的培养基中,nigericin对ADP诱导的血小板聚集几乎没有影响,轻微抑制凝血酶诱导的血小板聚集。此外,nigericin也降低细胞质pH值。Nigericin对血小板聚集的影响主要是由于其对细胞质pH的影响[1]。K+离子载体nigericin作为Pb2+的离子载体非常有效。生理浓度的Ca2+或Mg2+不抑制nigericin催化的Pb2+运输,而K+和Na+浓度(0-100 mM)小幅影响Pb2+运输。Nigericin可能有助于治疗铅中毒[2]。在低浓度(5 μM)和高浓度(1.5 mM)ATP下,nigericin均抑制ATP驱动的转氢反应,在低ATP浓度下效果更显著。在2.5 mM ATP浓度下,nigericin诱导三倍的羰醇反应[3]。
参考文献:
[1]. Kitagawa S, Awai M, Kametani F. Relationship of the effects of nigericin on the aggregation and cytoplasmic pH of bovine platelets in the presence of different cations. Biochim Biophys Acta, 1987, 930(1): 48-54.
[2]. Hamidinia SA, Tan B, Erdahl WL, et al. The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin. Biochemistry, 2004, 43(50): 15956-15965.
[3]. Eytan GD, Carlenor E, Rydström J. Energy-linked transhydrogenase. Effects of valinomycin and nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J Biol Chem, 1990, 265(22): 12949-12954.
产品性质
物理外观 | Solid |
CAS号 | 28643-80-3 |
分子式 | C40H67NaO11 |
分子量 | 746.94 |
化学名称 | sodium (S)-2-((2R,3S,6R)-6-(((2S,4S,5R,7R,9S,10R)-2-((2R,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7- |
溶解度 | insoluble in H2O; insoluble in DMSO; ≥74.7 mg/mL in EtOH |
SMILES | O[C@@]1(CO)O[C@@H]([C@@H](C)C[C@H]1C)[C@@H]2O[C@H]([C@@H](C)C2)[C@]3(C)O[C@H](CC3)[C@@]4(C)O[C@]([C@@H](C)C4)([C@@H]5C)O[C@H](C[C@@H]6O[C@@H]([C@@H](C([O-])=O)C)[C@@H](C)CC6)C[C@@H]5OC.[Na+] |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Lvyuan Fan, Zhiyu Pan, et al. "L-glutamine sensitizes Gram-positive-resistant bacteria to gentamicin killing." Microbiol Spectr. 2023 Dec 12;11(6):e0161923. PMID: 37882580
- 2. Yuan-Li Ai, Wei-Jia Wang, et al. "Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P." Cell Res. 2023 Jul 17. PMID: 37460805
- 3. Schwartz, Hannah, et al. "In vitro Methods to Better Evaluate Drug Responses in Cancer." UMass Chan Medical School. September 8, 2022.
- 4. Di Wu, Xiangyu Zhu, et al. "Delivery of Ultrasmall Nanoparticles to the Cytosolic Compartment of Pyroptotic J774A.1 Macrophages via GSDMDNtermMembrane Pores." ACS Appl Mater Interfaces. 2021 Nov 3;13(43):50823-50835. PMID: 34689556
- 5. Wang J, Luo J, et al. "Increased intracellular Cl(-) concentration by activating FAK promotes airway epithelial BEAS-2B cells proliferation and wound healing." Arch Biochem Biophys. 2019 Dec 12:108225. PMID: 31838119
- 6. Antonopoulos, Christina, et al. "Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling." Journal of Biological Chemistry (2015): jbc-M115. PMID: 26100631