Catalog No. A8183
Trichostatin A (TSA)(别名:Trichostatin A, 曲古柳菌素A)
HDAC抑制剂
![](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fproduct%2FA8183%2Fa8183.png&w=3840&q=75)
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mL(10 mM in DMSO) | ¥1909.00 | 现货 | |
1mg | ¥545.00 | 现货 | |
5mg | ¥1727.00 | 现货 | |
25mg | ¥6363.00 | 现货 | |
100mg | ¥16363.00 | 现货 |
CAS号:58880-19-6纯度:98.22%
仅用于科研,不用于诊疗。未经明确授权不得转售。
A
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特色产品
![Cy5 TSA Fluorescence System Kit](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1038%EF%BC%8CK1050-K1052_1.png&w=3840&q=75)
Cy5 TSA Fluorescence System Kit
Cy5荧光标记的酪胺信号放大系统
- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
![EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1079-K1081_1.png&w=3840&q=75)
EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)
用于观察mRNA运送,定位,翻译
- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Trichostatin A (TSA)是一种有效的组蛋白去乙酰化酶(HDAC)抑制剂,也是一种抗真菌类抗生素,具有抑制细胞生长和诱导细胞分化的特性。在培养的哺乳动物细胞以及分离的细胞核提取物中,TSA在低浓度时可以非竞争性并可逆地抑制HDAC。TSA能够使细胞停滞在G1和G2期,诱导细胞分化,恢复培养细胞的转化形态。据报道,在人乳腺癌细胞系中,TSA抑制乳腺癌细胞的增值(IC50值为 124.4 ± 120.4 nM),并导致组蛋白H4的超乙酰化。
参考文献:
David M. Vigushin, Simak Ali, Paul E. Pace, Nina Mirsaidi, Kazuhiro Ito, Ian Adcock, and R. Charles Coombes. Trichostatin A is a histone deacetylase inhibitor with potent antitumot activity against breast cancer in vivo. Clin Cancer Res 2001;7:971-976
产品性质
物理外观 | Solid |
CAS号 | 58880-19-6 |
分子式 | C17H22N2O3 |
分子量 | 302.37 |
小分子别名 | Trichostatin A |
化学名称 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
溶解度 | insoluble in H2O; ≥15.12 mg/mL in DMSO; ≥16.56 mg/mL in EtOH with ultrasonic |
SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
存储条件 | -20°C干燥 |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
产品应用 (实验数据来自文献,APExBIO并未验证,仅供参考)
IC50和靶点
靶点 | HDAC |
生物活性数据 | ~1.8 nM |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Min Yang, et al. "Trichostatin A enhances the titanium rods osseointegration in osteoporotic rats by the inhibition of oxidative stress through activating the AKT/Nrf2 pathway." Sci Rep. 2023 Dec 27;13(1):22967. PMID: 38151509
- 2. Haitao Wen, Jianwen Chen, et al. "Repression of ferroptotic cell death by mitochondrial calcium signaling." Res Sq. 2023 Jul 10;rs.3.rs-3029860. PMID: 37502961
- 3. Joseph Boyle, Derick Chiappo, et al. "Aminocoumarin-based heme oxygenase activity fluorescence probe reveals novel aspects of HO-1 regulation." Research Square. 22 Nov, 2023.
- 4. Zhang J, Ouyang Z, et al. "Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes." Cell Death Discov 2023 Jan 18;9(1). PMID: 36653336
- 5. Yoichiro Kawamura, Lingyang Hua, et al. "Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma." Biomed Pharmacother. 2022 Nov;155:113843. PMID: 36271587
- 6. Jan Zimak, Zachary W Wagoner, et al. "Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits." Sci Rep. 2021 Jan 28;11(1):2424. PMID: 33510302
- 7. Tianliang Li, Ligang Kong, et al. "Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit lc3-associated phagocytosis as a survival strategy." Nat Microbiol. 2021 Mar;6(3):366-379. PMID: 33462436
- 8. Somayeh Layeghi-Ghalehsoukhteh, Shreoshi Pal Choudhuri, et al. "Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics." Sci Rep. 2020 Nov 26;10(1):20662. PMID: 33244070
- 9. Haiyang Yu, Shan Lu, et al. "TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli." bioRxiv. March 29, 2020.
- 10. Xu W, Huang M, et al. "The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer." Int J Biol Sci. 2020;16(8):1388-1402. PMID: 32210727
- 11. Tang Y, Yu W. "SIRT1 and p300/CBP regulate the reversible acetylation of serine-threonine kinase NDR2." Biochem Biophys Res Commun. 2019 Aug 16. pii: S0006-291X(19)31586-4. PMID: 31427083
- 12. Dhana Friedrich, Laura Friedel, et al. "Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency." bioRxiv. 2019 June 21.
- 13. Wang MH, Wu CH, et al. "Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls." Dev Biol. 2019 May 15;449(2):122-131. PMID: 30826398
- 14. Zheng Q, Liu P, et al. "Mitochondrion-processed TERC regulates senescence without affecting telomerase activities." Protein Cell. 2019 Feb 20. PMID: 30788732
- 8. Sheridan J.S. Carrington. "Differential Glycosylation of the Inwardly Rectifying Potassium Channel Kir7.1 by G protein-coupled Receptors." Vanderbilt University. 2019.
- 16. Ling H, Peng L, et al. "Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication." Cell Rep. 2018 Dec 4;25(10):2851-2865.e3. PMID: 30517871
- 17. Jiang H, Zhang S, et al. "Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/Glycolytic Pathway." Front Pharmacol. 2018 Jun 11;9:612. PMID: 29942258
- 18. Prasad H, Rao R. "Histone deacetylase-mediated regulation of endolysosomal pH." J Biol Chem. 2018 Mar 22. pii: jbc.RA118.002025. PMID: 29567836
- 19. Choi S, Uehara H, et al. "RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through soluble FLT-1 upregulation." PLoS One. 2018 Mar 6;13(3):e0193590. PMID: 29509796
- 20. Rajini Rao, Hari Prasad. "A conserved mechanism for regulation of endo-lysosomal pH by histone deacetylases." bioRxiv. 2018 January 22.
- 21. Hari Prasad, Rajini Rao. "The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6." bioRxiv. 2018.January. 4
- 22. Yan Y, Wang H, et al. "HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila." Dev Cell. 2017 Oct 9;43(1):99-111.e5. PMID: 28966044
- 23. Hai Y, Shinsky SA, et al. "Histone deacetylase 10 structure and molecular function as a polyamine deacetylase." Nat Commun. 2017 May 18;8:15368. PMID: 28516954
- 24. Mitani Y, Vagnozzi RJ, Millay DP. "In vivo myomaker-mediated heterologous fusion and nuclear reprogramming. FASEB J. 2017 Jan;31(1):400-411." PMID: 27825107
- 25. Cai D, Wang X, et al. "Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators." Antiviral Res. 2016 May 13;132:26-37. PMID: 27185623
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