Catalog No. B3252
Dorsomorphin (Compound C)(别名:Dorsomorphin)
AMPK抑制剂
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥454.00 | 现货 | |
10mg | ¥681.00 | 现货 | |
50mg | ¥2272.00 | 现货 |
CAS号:866405-64-3纯度:99.45%
仅用于科研,不用于诊疗。未经明确授权不得转售。
A
021-55669583sales@apexbio.cnAPExBIO
特色产品
Cy5 TSA Fluorescence System Kit
Cy5荧光标记的酪胺信号放大系统
- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)
用于观察mRNA运送,定位,翻译
- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Dorsomorphin是细胞渗透性的\可逆的和ATP竞争性的AMP激活蛋白激酶(AMPK)抑制剂,Ki值为109 nM[1].
相较其他结构相关的激酶,如蛋白激酶A\蛋白激酶C和Janus激酶3,dorsomorphin对AMPK具有高选择性.在葡萄糖剥夺的小鼠神经干细胞中,dorsomorphin作为AMPK抑制剂,被发现可逆地抑制AMPK信号通路诱导的抗增殖.在小鼠3T3-L1成纤维细胞中,dorsomorphin显示出成脂分化的抑制作用[2].
Dorsomorphin也被报道是BMP信号通路的抑制剂.它能抑制Smad 1 / 5 / 8的磷酸化作用,从而减少异位骨化.也可以降低肝脏hepcidin的基因转录,随后导致铁水平升高.此外,dorsomorphin对BMP的抑制作用促进人ESC的自我更新和神经诱导[2].
参考文献:
[1] Lu Y, Akinwumi BC, Shao Z, Anderson HD. Ligand Activation of Cannabinoid Receptors Attenuates Hypertrophy of Neonatal Rat Cardiomyocytes. J Cardiovasc Pharmacol. 2014 Jun 26.
[2] Kudo T, Kanetaka H, Mizuno K, et al. Effects of the Small Molecule Dorsomorphin on Intracellular Signaling. Interface Oral Health Science 2011. Springer Japan, 2012: 131-133.
产品性质
物理外观 | A solid |
CAS号 | 866405-64-3 |
分子式 | C24H25N5O |
分子量 | 399.49 |
小分子别名 | Dorsomorphin |
化学名称 | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
溶解度 | insoluble in H2O; insoluble in EtOH; ≥8.49 mg/mL in DMSO with gentle warming and ultrasonic |
SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Yan Xu, et al. "AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia." Cell Signal. 2024 Jun:118:111125. PMID: 38432574
- 2. Zimengwei Ye, Yi Zhao, et al. "Exploring the Therapeutic Mechanism of Jiangtang Sanhao Formula in Alleviating Insulin Resistance in Skeletal Muscle Cells: Involvement of AMPK/SIRT1/PGC-1α pathway?" Research Square. 19 Oct, 2023.
- 3. Yuan-Li Ai, Wei-Jia Wang, et al. "Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P." Cell Res. 2023 Jul 17. PMID: 37460805
- 4. Xiaomeng Pei, Haolin Li, et al. "APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats." Cells. 2023 May 15;12(10):1393. PMID: 37408227
- 5. Taiyang Liao, Wei Mei, et al. "L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway." J Orthop Surg Res. 2023 May 26;18(1):386. PMID: 37237380
- 6. Fangjun Lin, Yan Liu, et al. "Adiponectin Enhances Fatty Acid Signaling in Human Taste Cells by Increasing Surface Expression of CD36." Int J Mol Sci. 2023 Mar 18;24(6):5801. PMID: 36982874
- 7. Truzzi F, Whittaker A, et al. "Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy." Int J Mol Sci 2023 Feb 18;24(4). PMID: 36835540
- 8. Jinjing Jia, Jiayi Yin, et al. "Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease." ASN Neuro. 2023 Jan-Dec:15:17590914231159226. PMID: 36823760
- 9. Liaoyuan Huang, Jianming Chen, et al. "Berberine Attenuates IL-1β-Induced Damage of Nucleus Pulposus Cells via Activating the AMPK/mTOR/Ulk1 Pathway." Biomed Res Int. 2022 Jul 23;2022:6133629. PMID: 35915801
- 10. Cheol Ho Park, Bin Lee, et al. "Canagliflozin protects against cisplatin-induced acute kidney injury by AMPK-mediated autophagy in renal proximal tubular cells." Cell Death Discov. 2022 Jan 10;8(1):12. PMID: 35013111
- 11. Liping Liang, Shiwei Ye, et al. "Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling." Int Immunopharmacol. 2022 Mar;104:108306. PMID: 34999396
- 12. Xiuyan Wang, Bin Song, et al. "LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway." J Cell Mol Med. 2021 Sep;25(17):8174-8186. PMID: 34309216
- 13. Mengmeng Chen, Chunmei Zhang, et al. "Metformin alleviates oxidative stress‐induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration." J Cell Mol Med. 2021 Sep;25(17):8376-8389. PMID: 34296521
- 14. Jingui Hu, Ling Zhang, et al. "Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy." Journal of Ginseng Research.Available online 3 July 2021.
- 15. Weipeng Hu, Shan Jiang, et al. "High phosphate impairs arterial endothelial function through AMPK‐related pathways in mouse resistance arteries." Acta Physiologica.
- 16. Si-wei Wang, Wen Wang, et al. "Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway." Int Immunopharmacol. 2020 Oct 14;89(Pt B):107036. PMID: 33068864
- 17. Lei L, Chai Y, et al. "Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice." Front Pharmacol. 2020;11:662. PMID: 32508636
- 18. Yang PM, Hong YH, et al. "Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units." Oxid Med Cell Longev. 2020 Apr 4;2020:7289120. PMID: 32322337
- 19. Su K, Yi B, et al. "Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis." Pharmacol Res. 2020;156:104778. PMID: 32247822
- 20. Xie B, Zhao M, et al. "Induction of autophagy and suppression of type I IFN secretion by CSFV." Autophagy. 2020;1-23. PMID: 32160078
- 21. Lu Q, Liu J, et al. "Empagliflozin attenuates ischemia and reperfusion injury through LKB1/AMPK signaling pathway." Mol Cell Endocrinol. 2019 Nov 20:110642. PMID: 31759100
- 22. Xiao J, Yang R, et al. "A role of AMPK and connexin 43 in the suppression of CoCl(2)-induced apoptosis of spiral modiolar artery smooth muscle cells by adiponectin." Life Sci. 2019 Oct 23:116876. PMID: 31655194
- 23. White SM, Avantaggiati ML, et al. "YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells." Dev Cell. 2019 May 6;49(3):425-443.e9. PMID: 31063758
- 24. Wei Q, Zhang B, et al. "Maslinic Acid Inhibits Colon Tumorigenesis by the AMPK-mTOR Signaling Pathway." J Agric Food Chem. 2019 Apr 17;67(15):4259-4272. PMID: 30913881
- 25. Tian L, Cao W, et al. "Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway." J Pharmacol Sci. 2019 Apr;139(4):352-360. PMID: 30910451
- 26. Liu Y, Hu X, et al. "Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway." Cancer Cell Int. 2019 Jan 11;19:13. PMID: 30651718
- 27. Li X, Liu J, et al. "Dichloroacetate ameliorates cardiac dysfunction caused by ischemic insults through AMPK signal pathway- not only shifts metabolism." Toxicol Sci. 2018 Oct 29. PMID: 30371859
- 28. He GR, Lin XK, et al. "Dexmedetomidine impairs P glycoprotein mediated efflux function in L02 cells via the adenosine 5' monophosphate activated protein kinase/nuclear factor κB pathway." Mol Med Rep.2018 Apr;17(4):5049-5056. PMID: 29393492
摩尔浓度计算器
质量
= 浓度
x 体积
x 分子量
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Apexbio的产品页面获得)批次特异的分子量使用本工具。