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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥504.00 | 现货 | |
10mg | ¥909.00 | 现货 | |
50mg | ¥3681.00 | 现货 |
特色产品
![Cy5 TSA Fluorescence System Kit](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1038%EF%BC%8CK1050-K1052_1.png&w=3840&q=75)
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
![EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1079-K1081_1.png&w=3840&q=75)
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
ST271是蛋白酪氨酸激酶(PTK)的有效抑制剂,抑制由fMet-Leu-Phe和PAF刺激的磷脂酶D的激活,IC50s分别为6.7和9μM[1]。ST271在膜制备和通透性血小板中部分抑制肽的磷酸化[2]。ST271(100μM)完全抑制FcγRII交联诱导的肌醇磷酸酯的形成,但也诱发了对凝血酶和U46619小幅度(<30%)却显著的响应抑制[3]。
参考文献:
[1]. Uings IJ, Thompson NT, Randall RW, Spacey GD, Bonser RW, Hudson AT, Garland LG. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt3) (Pt 3):597-600. doi: 10.1042/bj2810597. Erratum in: Biochem J 1992 May 1;283(Pt 3):919. PMID: 1371383; PMCID: PMC1130730.
[2]. Martinson EA, Scheible S, Presek P. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID: 7526916.
[3]. Blake RA, Asselin J, Walker T, Watson SP. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor. FEBS Lett. 1994 Mar 28;342(1):15-8. doi: 10.1016/0014-5793(94)80575-x. PMID: 8143842.
产品性质
物理外观 | Solid |
CAS号 | 106392-48-7 |
分子式 | C16H20N2O2 |
分子量 | 272.34 |
化学名称 | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide |
溶解度 | ≥25.9 mg/mL in DMSO |
SMILES | O=C(/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1)N |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |