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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥2762.00 | 现货 | |
10mg | ¥4495.00 | 现货 | |
25mg | ¥9479.00 | 现货 |
特色产品
![Cy5 TSA Fluorescence System Kit](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1038%EF%BC%8CK1050-K1052_1.png&w=3840&q=75)
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
![EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1079-K1081_1.png&w=3840&q=75)
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
IC50: 0.03 and 0.36 μM for COX-2 and COX-1, respectively
Inotilone is a cyclooxygenase (COX) inhibitor.
Many of nonsteroidal anti-inflammatory drugs (NSAIDs) target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid.
In vitro: Inotilone was tested as the inhibitor of mitogen-activated protein kinase, nuclear factor-κB (NF-κB), and matrix-metalloproteinase (MMP)-9 protein expressions in LPS-stimulated RAW264.7 cells. When RAW264.7 macrophages were treated with inotilone with LPS, a significant concentration-dependent inhibition of NO production was detected. It was also found that inotilone could block the protein expression of iNOS, NF-κB, and MMP-9 in LPS-stimulated RAW264.7 macrophages [1].
In vivo: In in vivo tests, inotilone decreased the paw edema after Carr administration, and it increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Inotilone also significantly attenuated the malondialdehyde (MDA) level in the edema paw. Inotilone decreased the NO and tumor necrosis factor (TNF-α) levels on serum after Carr injection. In addition, an intraperitoneal injection treatment with inotilone could diminish neutrophil infiltration into sites of inflammation, as did indomethacin [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Huang GJ, Huang SS, Deng JS. Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo. PLoS One. 2012;7(5):e35922.
产品性质
物理外观 | A crystalline solid |
CAS号 | 906366-79-8 |
分子式 | C12H10O4 |
分子量 | 218.2 |
化学名称 | (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone |
溶解度 | ≤1mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
SMILES | OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |