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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mg | ¥9373.00 | 现货 | |
5mg | ¥35156.00 | 现货 |
特色产品
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- 使用5-moUTP和Cy5-utp修饰
产品描述
24,25-二羟基维生素D3[24,25(OH)2D3]是维生素D(VD [1])的类似物,可抑制一些代谢过程。在肠上皮细胞中,24, 25-Dihydroxy VD3剂量依赖性地抑制细胞内10 mM Ca2+诱发的Ca2+浓度的增加,EC50值为4.9 nM[2]。
维生素D在钙平衡、骨骼维持和骨骼发育中具有重要作用。两个连续的反应参与VD的形成:第一个是25-羟基维生素D(25OHD)的形成;第二个是1α,25二羟基维生素D [1,25(OH)2D]的形成,它是维生素D的活性形式[3]。
Ca2+在10 mM浓度时通常可增加[Ca2+]i,即从基础值203±13 nM增加到一个新的稳定值264±16 nM。24R, 25(OH)2D3在0.2 pM-202 nM浓度时,在第一个18秒(t= 300-318 s)和最终的[Ca2+]i增加(t= 550-600 s)阶段剂量依赖性地抑制初始[Ca2+]i的增加,EC50值分别为4.9 nM和30 nM。24R, 25(OH)2D3在20 nM浓度时获得对Ca2+吸收的最大抑制(约60%)[2]。
在肾功能不全的成年雌性杂种狗中,与对照(CK)相比,24,25(OH)2D3显著减少离子钙,而对总钙没有影响。在第二周时这一下降趋势明显。24,25-(OH)2D3再处理4周后导致离子钙非常小的额外减少。24,25(OH)2D3引起狗中略正的钙平衡,而在对照狗中则是略负的钙平衡[4]。
参考文献:
[1]. Dennis Wagner, Heather E. Hanwell, Kareena Schnabl, et al. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. Journal of Steroid Biochemistry & Molecular Biology, 2011, 126:72-77.
[2]. D Larsson, L Aksnes, B Th Bjrnsson, et al. Antagonistic effects of 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 on L-type Ca2+ channels and Na+/Ca2+ exchange in enterocytes from Atlantic cod (Gadus morhua). Journal of Molecular Endocrinology, 2002, 28:53-68.
[3]. Thomas Edouard, Abdallah Husseini, Francis H. Glorieux, et al. Serum 24,25-Dihydroxyvitamin D Concentrations in Osteogenesis Imperfecta: Relationship to Bone Parameters. J. Clin. Endocrinol. Metab., 2012, 97(4):0000-0000.
[4]. Janet M. Canterbury, George Gavellas, Jacques J. Bourgoignie, et al. Metabolic Consequences of Oral Administration of 24,25-Dihydroxycholecalciferol to Uremic Dogs. J. Clin. Invest., 1980, 65(3):571-576.
产品性质
物理外观 | Solid |
CAS号 | 40013-87-4 |
分子式 | C27H44O3 |
分子量 | 416.64 |
化学名称 | (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol |
溶解度 | Soluble in DMSO |
SMILES | CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1.Xue, Ying, et al. "Simultaneous Quantification of 25-Hydroxyvitamin D3 and 24, 25-Dihydroxyvitamin D3 in Rats Shows Strong Correlations between Serum and Brain Tissue Levels." International journal of endocrinology 2015 (2015). PMID:26713090
- 2.He X, Jiang P, Xue Y, et al. "Simultaneous analysis of 25OHD 3 and 24, 25 (OH) 2 D 3 both in human serum and cerebrospinal fluid by LC-MS/MS[J]."Analytical Methods, 2016, 8(11): 2400-2407.