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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥836.00 | 现货 | |
10mg | ¥1454.00 | 现货 | |
25mg | ¥3163.00 | 现货 |
特色产品
![Cy5 TSA Fluorescence System Kit](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1038%EF%BC%8CK1050-K1052_1.png&w=3840&q=75)
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
![EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1079-K1081_1.png&w=3840&q=75)
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
IC50: ~30 μM
Ubiquitin Isopeptidase Inhibitor I is a ubiquitin isopeptidase inhibitor.
Conjugation or deconjugation of ubiquitin or ubiquitin-like proteins to or from cellular proteins is a multifaceted and universal ways of regulating cellular physiology, controlling the lifetime, localization, and activity of various key proteins.
In vitro: Ubiquitin Isopeptidase Inhibitor I targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. Ubiquitin Isopeptidase Inhibitor I could induce a rather unique apoptotic pathway, including a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. Moreover, the treatment of Ubiquitin Isopeptidase Inhibitor I to cell extracts obtained from E1A cells did not inhibit the proteolytic activity of the proteasome, whereas MG-132 potently inhibited the cleavage of the LLVY-AMC substrate. In addition, Noxa induction by Ubiquitin Isopeptidase Inhibitor I could be inhibited by the specific RNAi oligos efficiently. When apoptosis was scored, it was found that down-regulation of Noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to Ubiquitin Isopeptidase Inhibitor I treatment [1].
In vivo: So far, there is no animal in vivo data reported.
Clinical trial: Up to now, Ubiquitin Isopeptidase Inhibitor I is still in the preclinical development stage.
Reference:
[1] E. Aleo, C. J. Henderson, A. Fontanini, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Research 66(18), 9235-9244 (2006).
产品性质
物理外观 | A crystalline solid |
CAS号 | 108477-18-5 |
分子式 | C19H14N2O7S |
分子量 | 414.4 |
小分子别名 | Ubiquitin Isopeptidase Inhibitor I, G5 |
化学名称 | tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide |
溶解度 | ≤15mg/ml in DMSO;1mg/ml in dimethyl formamide |
SMILES | O=C(/C(CS(C/1)(=O)=O)=C\C2=CC=C([N+]([O-])=O)C=C2)C1=C/C3=CC=C([N+]([O-])=O)C=C3 |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |