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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥545.00 | 现货 | |
25mg | ¥1818.00 | 现货 |
特色产品
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- 可将信号灵敏度提高100倍
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Perifosine是Akt的抑制剂[1]。
Perifosine是一种合成的抗肿瘤烷基磷脂,通过抑制Akt的活性诱导细胞凋亡。Perifosine在不同的细胞系中均具有抗肿瘤活性,包括非小细胞肺癌(NSCLC)、MM、上皮癌、前列腺癌和白血病细胞。在H460细胞中,perifosine减少细胞存活,诱导细胞凋亡,IC50值分别为1 μM和10 μM。Perifosine也可以诱导caspase-8、caspase-9、caspase-3和PARP的切割。在MM.1S细胞中,perifosine在10 μM浓度时诱导亚G1期细胞数量的增多,从15%增加到57%,并以剂量依赖的方式诱导caspase-8、caspase-9和PARP的切割。在接种MM.1S细胞的小鼠中,perifosine口服给药后显著减少MM肿瘤的生长,增加存活率[1,2]。
参考文献:
[1] Elrod H A, Lin Y D, Yue P, et al. The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Molecular cancer therapeutics, 2007, 6(7): 2029-2038.
[2] Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood, 2006, 107(10): 4053-4062.
产品性质
物理外观 | A solid |
CAS号 | 157716-52-4 |
分子式 | C25H52NO4P |
分子量 | 461.67 |
化学名称 | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate |
溶解度 | insoluble in DMSO; ≥5.55 mg/mL in EtOH with ultrasonic; ≥5.94 mg/mL in H2O with ultrasonic |
SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
产品应用 (实验数据来自文献,APExBIO并未验证,仅供参考)
IC50和靶点
生物活性描述 | Perifosine (KRX-0401)是一种新型Akt抑制剂,IC50值为4.7 μM。 |
靶点 | Akt |
生物活性数据 | 4.7 μM |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Jialin He, Jianyang Liu, et al. "OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway." Oxid Med Cell Longev. 2021 Nov 13;2021:4805040. PMID:34815829
- 2. Zi-Yan Yang, Liu Yang, et al. "An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway." Biol Open. 2020 Jan 24;9(1):bio047662. PMID:31980423
- 3. Chen H, Wang X, et al. "AKT and its related molecular feature in aged mice skin." PLoS One. 2017 Jun 7;12(6):e0178969. PMID:28591208