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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mL(10 mM in DMSO) | ¥500.00 | 现货 | |
25mg | ¥636.00 | 现货 | |
50mg | ¥954.00 | 现货 | |
100mg | ¥1363.00 | 现货 |
特色产品
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- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
IC 50:41 nM,作用于I型腺苷酸环化酶。
环磷酸腺苷(cAMP)是一种第二信使,在生物过程中非常重要。Forskolin(毛喉素)是植物毛喉鞘蕊活化腺苷酸环化酶衍生的二萜。腺苷酸环化酶可增加细胞内cAMP的水平。Forskolin的抗炎和抗氧化作用是由于对巨噬细胞激活的抑制,从而减少血栓素B2和超氧化物的水平。该特性使得forskolin成为一种有效的药物,用于治疗心脏病、高血压、糖尿病和哮喘。
体外实验:Forskolin对腺苷酸环化酶的激活导致多种真核细胞内环AMP水平的显著增加。而低浓度forskolin通过增强完整细胞内腺苷酸环化酶的激活,只能少量增加细胞内环AMP。Forskolin也产生依赖于环AMP作为第二信使的细胞内反应[1]。
体内实验:与健康雄性Wistar大鼠相比,评估forskolin慢性给药对streptozotocin诱导的糖尿病雄性Wistar大鼠血糖和氧化应激的影响。在健康和糖尿病大鼠中,在实验结束时,forskolin降低了空腹血糖的水平[2]。
临床试验:一个单盲实验用于比较口服forskolin与吸入倍氯米松(beclomethasone)对轻度或中度持续性成人哮喘的疗效。结果表明,forskolin和倍氯米松治疗组的任何肺功能参数均没有统计学显著的差异。倍氯米松治疗组的患者没有哮喘发作,而forskolin治疗组有一个患者在2个月的研究期间出现了轻度哮喘发作[3]。
参考文献:
[1] Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24.
[2] Ríos-Silva M, Trujillo X, Trujillo-Hernández B, Sánchez-Pastor E, Urzúa Z, Mancilla E, Huerta M. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52.
[3] Huerta M, Urzúa Z, Trujillo X, González-Sánchez R, Trujillo-Hernández B. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial. J Int Med Res. 2010 Mar-Apr;38(2):661-8.
产品性质
物理外观 | A solid |
CAS号 | 66575-29-9 |
分子式 | C22H34O7 |
分子量 | 410.5 |
化学名称 | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate |
溶解度 | insoluble in H2O; ≥13.43 mg/mL in EtOH; ≥20.53 mg/mL in DMSO |
SMILES | C[C@]1([C@@H]([C@@H]2O)C(C)(C)CC[C@@H]1O)[C@]3(O)[C@]([C@H]2OC(C)=O)(C)O[C@@](C)(C=C)CC3=O |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Sneha Kesaraju, Yueying Li, et al. "Claudin-2 limits pancreatitis development through regulating tight junction-controlled pancreatic ductal transport." bioRxiv. September 11, 2023
- 2. Lina Xu, Guoliang Wang, et al. "A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells." Ocul Surf. 2023 Aug 25;S1542-0124(23)00109-X. PMID: 37634570
- 3. Blackford SJI, Yu TTL, et al. "RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling." Biomaterials 2023 Feb;293 PMID: 36640555
- 4. Lu Gan, Qiyong Li, et al. "Glucocorticoids rapidly promote YAP phosphorylation via the cAMP-PKA pathway to repress mouse cardiomyocyte proliferative potential." Mol Cell Endocrinol. 2022 Mar 10;548:111615. PMID: 35278645
- 5. Xiaoya An, Guoliang Wang, et al. "Novel cell culture paradigm prolongs mouse corneal epithelial cell proliferative activity in vitro and in vivo." Front Cell Dev Biol. 2021 Jun 30;9:675998. PMID: 34277619
- 6. Emilio J Vélez, Suraj Unniappan. "Nesfatin-1 and nesfatin-1-like peptide suppress growth hormone synthesis via the AC/PKA/CREB pathway in mammalian somatotrophs." Sci Rep. 2020 Oct 7;10(1):16686. PMID: 33028951
- 7. Liu DT, Hong WS, et al. "Upregulation of adamts9 by gonadotropin in preovulatory follicles of zebrafish." Mol Cell Endocrinol. 2019 Oct 2;499:110608. PMID: 31586455
- 8. Zhang H, Wen JJ, et al. "Forskolin reduces fat accumulation in Nile tilapia (Oreochromis niloticus) through stimulating lipolysis and beta-oxidation." Comp Biochem Physiol A Mol Integr Physiol. 2018 Dec 26;230:7-15. PMID: 30593869
- 9. Morel JD, Paatero AO, et al. "Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature." Mol Cell Proteomics. 2018 Jun 18. pii: mcp.RA118.000824. PMID: 29915147