![](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fproduct%2FB7389%2Fb7389.png&w=3840&q=75)
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5mg | ¥1083.00 | 现货 | |
10mg | ¥2058.00 | 现货 | |
25mg | ¥3033.00 | 现货 |
特色产品
![Cy5 TSA Fluorescence System Kit](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1038%EF%BC%8CK1050-K1052_1.png&w=3840&q=75)
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
![EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)](/_next/image?url=https%3A%2F%2Fresource.apexbio.cn%2Fapexbio%2Fbanner%2FK1079-K1081_1.png&w=3840&q=75)
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
EIPA is a TRPP3 channel inhibitor with an IC50 value of 10.5 μM, EIPA also inhibits Sodium-hydrogen exchangers (NHE) and macropinocytosis[1].
In Chinese hamster ovary cells, EIPA is a Na+/Ca2+ exchange (NCX) inhibitor that inhibits ET-1-induced continuous increase of intracellular Ca2+ concentration. In Xenopus oocytes, EIPA can rapidly and reversibly block calcium ion-activated TRPP3 channel activation at -50mV and other membrane potentials[2].
References:
[1]. Dai X Q, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol, 2007, 72(6): 1576-85.
[2]. Horinouchi T, Miyake Y, Nishiya T, et al. Functional Role of Na+/H+ Exchanger in Ca2+ Influx Mediated via Human Endothelin Type A Receptor Stably Expressed in Chinese Hamster Ovary Cells. Journal of Pharmacological Sciences, 2008, 107(4): 456-459.
产品性质
物理外观 | A crystalline solid |
CAS号 | 1154-25-2 |
分子式 | C11H8ClN7O |
分子量 | 299.76 |
化学名称 | 3-amino-6-chloro-N-(diaminomethylene)-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide |
溶解度 | ≥32.1 mg/mL in DMSO; ≥13.9 mg/mL in EtOH; insoluble in H2O |
SMILES | ClC1=NC(C(/N=C(N)\N)=O)=C(N)N=C1N(CC)C(C)C |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
产品引用文献
- 1. Tiezhu Liu, Jiajia Li, et al. "Knockout of CLTC gene reduces but not completely block SFTSV infection." PLoS One. 2023 Aug 25;18(8):e0285673. PMID: 37624798
- 2. Jia Wen, Xiuge Gao, et al. "Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle." Pharmaceutics. 2021 Feb 25;13(3):303. PMID:33669090
- 3. Zhang Q, Yang H, et al. "Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin." Colloids Surf B Biointerfaces. 2019 Nov 17:110649. PMID:31767412
- 4. Li Y, Yang B, et al. "Oral delivery of imatinib through galactosylated polymeric nanoparticles to explore the contribution of a saccharide ligand to absorption." Int J Pharm. 2019 Jul 9;568:118508. PMID:31299337
- 5. Liu W, Zhang L, et al. "Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells." Bone Res. 2018 Sep 11;6:27. PMID:30210899
- 6. Siu FY, Ye S, et al. "Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity." Int J Nanomedicine. 2018 Jul 13;13:4133-4144. PMID:30038494
- 7. Gao W, Ye G, et al. "Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer." Int J Nanomedicine. 2017 Feb 7;12:1047-1064. PMID:28223798