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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mL(10 mM in DMSO) | ¥727.00 | 现货 | |
1g | ¥500.00 | 现货 | |
5g | ¥818.00 | 现货 |
特色产品
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
多巴胺受体是一类G蛋白偶联受体,在中枢神经系统中有突出地位.多巴胺受体参与多种神经过程.因此,多巴胺受体是常见的神经药物靶点.抗精神病药经常是多巴胺受体拮抗剂,而典型的神经兴奋剂则通常是多巴胺受体的间接激动剂.Chlorpromazine是一种多巴胺拮抗剂.
在体外:chlorpromazine的抗精神病活性与其拮抗多巴胺受体的功能有关,其具有吩噻嗪环结构,可与多巴胺受体相互作用.此外,chlorpromazine可抑制[3H]螺哌隆的结合,其抑制曲线与单一位点结合的类型相一致[1].
在体内:大鼠每天使用chlorpromazine持续21日可导致僵住症\对僵住症的耐受和PCP挑战带来的自主活动敏化.结果表明每日chlorpromazine治疗可诱导DA/NMDA受体对PCP挑战带来的总的自主活动敏感[2].
临床试验:Chlorpromazine在临床上是一种传统的抗精神病药,自从1954年被FDA批准后一直用于处理精神分裂.
参考文献:
[1] Harrold MW, Chang YA, Wallace RA, Farooqui T, Wallace LJ, Uretsky N, Miller DD. Charged analogues of chlorpromazine as dopamine antagonists. J Med Chem. 1987 Sep;30(9):1631-5.
[2] Nsimba SE. Effects of daily chlorpromazine administration on behavioural and physiological parameters in the rat. Indian J Physiol Pharmacol. 2009 Jul-Sep;53(3):209-18.
产品性质
物理外观 | Solid |
CAS号 | 69-09-0 |
分子式 | C17H19ClN2S·HCl |
分子量 | 355.33 |
小分子别名 | Chlorpromazine hydrochloride |
化学名称 | 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride |
溶解度 | ≥17.77 mg/mL in DMSO; ≥71.4 mg/mL in H2O; ≥74.8 mg/mL in EtOH |
SMILES | CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |
生物相关数据
质量控制
操作说明
产品引用文献
- 1. Xiaohai Song, Hao Cai, et al. "Enzyme‐Responsive Branched Glycopolymer‐Based Nanoassembly for Co‐Delivery of Paclitaxel and Akt Inhibitor toward Synergistic Therapy of Gastric Cancer." Adv Sci (Weinh). 2023 Nov 12:e2306230. PMID: 37953442
- 2. Yuxin Zhang, Jie Zhou, et al. "Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy." J Control Release. 2023 Apr:356:525-541. PMID: 36918084
- 3. Jun Wang, Wei Tang, et al. "Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy." Biomaterials. 2021 Jun;273:120784. PMID:33848731
- 4. Dong Y, Gao J, et al. "Antigen-Conjugated Silica Solid Sphere as Nanovaccine for Cancer Immunotherapy." Int J Nanomedicine. 2020;15:2685-2697. PMID:32368049
- 5. Zhou J, Ma S, et al. "Virus-Inspired Mimics: Dual-pH-Responsive Modular Nanoplatforms for Programmable Gene Delivery without DNA Damage with the Assistance of Light." ACS Appl Mater Interfaces. 2020;12(20):22519-22533. PMID:32329598
- 6. Wei P, Ning M, et al. "Spiroplasma eriocheiris entered Drosophila Schneider 2 cells and relied on clathrin-mediated endocytosis and macropinocytosis." Infect Immun. 2019 Aug 26. pii: IAI.00233-19. PMID:31451616