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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mg | ¥1137.00 | 现货 | |
5mg | ¥3141.00 | 现货 |
特色产品
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- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
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- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
C 021 dihydrochloride是CCR4的强效拮抗剂,对小鼠和人趋化性抑制的IC50值分别为0.039和0.14 μM[1].
CC趋化因子受体4(CCR4)是G蛋白偶合受体,是CC趋化因子的受体,在免疫系统的发育和功能中起重要作用.
C 021 dihydrochloride是一种有效的CCR4拮抗剂.C 021 dihydrochloride有效抑制小鼠和人的趋化功能,IC50值分别为0.039和0.14 μM.在GTPγS结合实验中,C 021 dihydrochloride的IC50值为0.018 μM[1].
使用氧化偶氮甲烷(AOM)处理小鼠,诱发肝性脑病,AOM显著增加小胶质细胞活化和肝脏\血清和皮质中CCL2的浓度.C 021 dihydrochloride减少肝损伤,显著改善神经功能.C 021 dihydrochloride降低小胶质细胞活化和ERK1/2的磷酸化,抑制AOM诱导的细胞因子上调[2].
参考文献:
[1]. Yokoyama K, Ishikawa N, Igarashi S, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem, 2009, 17(1): 64-73.
[2]. McMillin M, Frampton G, Thompson M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation, 2014, 11: 121.
产品性质
物理外观 | Pale yellow solid |
CAS号 | 864289-85-0 |
分子式 | C27H41N5O2·2HCl |
分子量 | 540.57 |
小分子别名 | C-021 |
化学名称 | 2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride |
溶解度 | Soluble in DMSO |
SMILES | COC1=CC2=C(N=C(N=C2N(C3CCCCCC3)[H])N4CCC(CC4)N5CCCCC5)C=C1OC.Cl.Cl |
存储条件 | -20°C |
运输条件 | 蓝冰 |
SDF文件 | Download SDF |