Y-39983 dihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Y-39983 dihydrochloride是新型的ROCK家族选择性抑制剂,对ROCK的IC50值为3.6 nM[1].
Y-39983 dihydrochloride是Rho相关卷曲螺旋形成蛋白激酶(ROCK)的选择性抑制剂,对ROCK\PKC和CaMKII的IC50值分别为3.6 nM\0.42 μM和0.81 μM[1].据报道, Y-39983可以放松预收缩离体兔的睫状动脉.激光散斑血流仪显示,Y-39983增加视神经头血流[2].此外,在兔和猴的眼睛中,Y-39983呈剂量依赖性地降低眼内压(IOP)[1].
参考文献：
[1] Tokushige H1, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, Tanihara H. Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3216-22.
[2] Watabe H1, Abe S, Yoshitomi T. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries. Jpn J Ophthalmol. 2011 Jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. Epub 2011 Jun 11.
| Storage | Store at -20°C |
| M.Wt | 353.25 |
| Cas No. | 173897-44-4 |
| Formula | C16H18Cl2N4O |
| Solubility | ≥18.05 mg/mL in DMSO; ≥6.34 mg/mL in EtOH with ultrasonic; ≥26.5 mg/mL in H2O |
| Chemical Name | 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC(C1=CC=C(C=C1)C(=O)NC2=C3C=CNC3=NC=C2)N.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
