WS6
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WS6是一种小分子的β细胞增殖诱导剂[1].
β细胞是胰岛中的一种细胞类型,通过产生胰岛素,在调节葡萄糖稳态中扮演重要作用[1].
WS6是一种小分子的β细胞增殖诱导剂.在小鼠β细胞系R7T1中,WS6可诱导细胞增殖,EC50值为0.28 M.WS6在原代人类和啮齿类胰岛中极具活性.在原代大鼠和人类β细胞中,WS6可诱导大鼠β细胞增殖,EC50值为0.4 M,并可增加4%的大鼠β细胞和3%的人类β细胞增殖.在完整胰岛培养物中,WS6可显著诱导增殖[1].在培养的人类胰岛中,WS6可诱导β细胞增殖和α细胞增殖.但是WS6不影响β细胞特异的转录因子表达和胰岛素阳性β细胞的数量,表明WS6不影响β细胞分化和人类胰岛细胞活力[2].
在I型糖尿病(T1D)小鼠中,WS6可显著降低血糖,并可将β细胞增殖从3.8%提高到6.4%[1].
参考文献:
[1]. Shen W, Tremblay MS, Deshmukh VA, et al. Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc, 2013, 135(5): 1669-1672.
[2]. Boerner BP, George NM, Mir SU, et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J, 2015, 62(4): 379-386.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 568.59 |
Cas No. | 1421227-53-3 |
Formula | C29H31F3N6O3 |
Solubility | insoluble in H2O; ≥11.52 mg/mL in EtOH; ≥15.95 mg/mL in DMSO |
Chemical Name | N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide |
SDF | Download SDF |
Canonical SMILES | CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
![WS6](http://www.apexbt.com//media/diy/images/struct/B4880.png)