TWS119
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TWS119是一种糖原合酶激酶-3β(GSK-3β)的抑制剂,IC50值为30 nM[1].
TWS119是从一个吡咯并嘧啶化合物的文库中筛选出来的,在小鼠P19 EC细胞中可选择性诱导神经元分化.TWS119可紧密结合GSK-3β,Kd值为126 nM,抑制能力的IC50值为30 nM.TWS119与GSK-3β的结合可调控复合体的活性,并可触发下游转录事件,从而引起神经诱导.除此之外,TWS119可通过另一机制,而非典型的Wnt信号通路,促进mESCs的神经元分化[1,2].
参考文献:
[1] Ding S, Wu T Y H, Brinker A, et al. Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences, 2003, 100(13): 7632-7637.
[2] Wu T Y H, Ding S. Applying chemical tools to the discovery of novel regenerative medicine. Drug Discovery Today: Technologies, 2006, 3(3): 255-260.
- 1. Eun-Ah Sung, Min Hee Park, et al. "Thrombocyte-derived Dickkopf1 promotes macrophage polarization in the Bleomycin-induced lung injury model." Frontiers in Immunology. 15 Dec 2023. 2. Croft CL, Cruz PE, et al. "rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies." J Exp Med. 2019 Mar 4;216(3):539-555. PMID:30770411
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 318.33 |
Cas No. | 601514-19-6 |
Formula | C18H14N4O2 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO |
Chemical Name | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol |
SDF | Download SDF |
Canonical SMILES | C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | TWS119是一种GSK-3β抑制剂,IC50值为30 nM. | |||||
靶点 | GSK-3β | |||||
IC50 | 30 nM |
质量控制和MSDS
- 批次:
化学结构
![TWS119](http://www.apexbt.com//media/diy/images/struct/B1540.png)
相关生物数据
![TWS119 TWS119](http://www.apexbt.com/media/diy/images/wb/B1540_1.jpg)