TS 155-2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TS 155-2, is a macrocyclic lactone related to hygrolidin, is produced by a different Streptomyces species found in oil. It blocks thrombin-evoked calcium (Ca2+) entry into cells. TS155-2 exerts hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity showed on the original patent, however, no literature investigation of TS155-2 is available.
A rapid increase in cytosolic Ca2+ is related to the signal transduction events following the induction of thrombin in a wide range of cell types which include fibroblasts, platelets, megakaryocytes, endothelium and smooth muscle. Thrombin-stimulated Ca2+ mobilization has been shown to be involved in both Ca2+ release from internal storage sites and Ca2+influx and has been extensively studied in human platelets. Thrombin triggers phospholipase C resulting in the rapid generation of inositol 1,4,5-trisphosphate (IP3), which elicits the release of Ca2+ from IP3-sensitive stores. However, the thrombin-induced Ca2+ influx is still an area of contention [1].
In vitro: Up to now, in vitro study of TS 155-2 is still in the development stage.
In vivo: Up to now, in vivo study of TS 155-2 is still in the development stage.
Reference:
[1]. Somasundaram, B., Mason, M., & Mahaut-Smith, M. Thrombin-dependent calcium signalling in single human erythroleukaemia cells. The Journal of Physiology.1997;501(3):485-495.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 704.9 |
Cas No. | 1314486-37-7 |
Formula | C39H60O11 |
Synonyms | JBIR 100 |
Solubility | Soluble in DMSO |
Chemical Name | 2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H |
SDF | Download SDF |
Canonical SMILES | C[C@H]([C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](OC(/C=C/C(O)=O)=O)C1)[C@H](O)[C@@H]([C@](OC(/C(C)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C |
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