TG101209
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
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Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TG101209是基于结构设计的小分子,是一种选择性的janus激酶2(Jak2)抑制剂,可有效抑制多发性骨髓瘤(MM)细胞系中的Jak/Stat通路,如含JAK2V617F或MPLW515L/K突变的细胞,其通常分别与真性红细胞增多症(PV)以及原发性骨髓纤维化(PMF)有关。根据多种研究结果显示,在大范围的多发性骨髓瘤细胞系中,TG101209通过抑制pJak2、pStat3和Bcl-xl的表达,诱导pErk和pAkt的过表达,具有剂量和时间依赖性的细胞毒性,这与抑制细胞周期进程和诱导细胞凋亡有关。
参考文献:
Ramakrishnan V, Kimlinger T, Haug J, Timm M, Wellik L, Halling T, Pardanani A, Tefferi A, Rajkumar SV, Kumar S. TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells. Am J Hematol. 2010;85(9):675-686.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 509.67 |
Cas No. | 936091-14-4 |
Formula | C26H35N7O2S |
Synonyms | TG-101209 |
Solubility | ≥25.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | N-tert-butyl-3-[[5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide |
SDF | Download SDF |
Canonical SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | TG101209是一种选择性的JAK2抑制剂,其IC50值为6 nM。 | |||||
靶点 | Flt3 | RET | JAK3 | |||
IC50 | 6 nM | 25 nM | 17 nM | 169 nM |
质量控制和MSDS
- 批次:
化学结构
![TG101209](http://www.apexbt.com//media/diy/images/struct/A4145.png)
相关生物数据
![TG101209 TG101209](http://www.apexbt.com/media/diy/images/wb/A4145_1.jpg)
相关生物数据
![TG101209 TG101209](http://www.apexbt.com/media/diy/images/wb/A4145_2.jpg)