Thrombin
Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.
- C4021 TS 155-2Summary: 大环内酯,抑制凝血酶刺激的钙进入细胞
- A8381 BIBR-1048中文名: 达比加群酯Summary: 凝血酶抑制剂
- A8363 Argatroban中文名: 阿加曲班Summary: 凝血酶介导的纤维蛋白原裂解抑制剂
- A5066 Heparin sodium中文名: 肝素钠Summary: 抗凝血酶III激活剂
- A3690 Otamixaban中文名: 奥米沙班Target: Factor XaSummary: 因子Xa抑制剂
- A3383 Edoxaban tosylate monohydrate中文名: 依多沙班对甲苯磺酸盐一水合物Summary: 口服Xa因子抑制剂
- A3381 Edoxaban中文名: 依度沙班Target: Factor XaSummary: 因子Xa抑制剂
- A3346 Dabigatran ethyl ester中文名: 达比加群乙酸乙酯Summary: 凝血酶活性抑制剂
- A3345 Dabigatran etexilate mesylate中文名: 甲磺酸达比加群酯Summary: 凝血酶抑制剂,抗凝剂,dabigatran的前药
- A3244 Bivalirudin TrifluoroacetateTarget: thrombinSummary: 凝血酶抑制剂