MMP
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
- C5818 MMP-2 Inhibitor IISummary: MMP-2的不可逆抑制剂
- C5615 MMP-2 Inhibitor ISummary: 基质金属蛋白酶(MMP)-2的可逆抑制剂
- C5598 MMP-2/MMP-9 Inhibitor ISummary: 基质金属蛋白酶-2(MMP-2)和MMP-9的有效抑制剂
- C4501 cis-ACCPSummary: IV型胶原特异性MMP-2和MMP-9抑制剂
- C4331 MMP-13 InhibitorSummary: MMP-13抑制剂
- C4081 MMP Inhibitor IISummary: MMPs抑制剂
- C3232 NNGHSummary: 细胞渗透性,广谱MMP抑制剂
- B5981 DC_AC50Summary: Atox1和CCS的选择性抑制剂
- A1038 Amyloid β-Peptide (10-20) (human)Summary: 在阿尔茨海默病中引发神经退行性病变。
- B4686 TAPI-12 CitationTarget: MMPSummary: TACE/ADAM17抑制剂