HCV Protease
Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
- A8898 HZ-1157Summary: HCV NS3/4A蛋白酶抑制剂
- A5618 Daclatasvir (BMS-790052)中文名: 达卡他韦Target: HCV ProteasesSummary: HCV NS5A抑制剂
- A3864 TegobuvirSummary: HCV RNA 复制抑制剂
- A3820 Simeprevir1 Citation中文名: 西咪匹韦Target: HCV ProteasesSummary: HCV NS3/4A蛋白酶抑制剂
- A3655 NesbuvirTarget: Nonstructural protein 5B (NS5B)Summary: NS5B聚合酶选择性抑制剂
- A3643 Narlaprevir中文名: 那拉匹韦Summary: NS3蛋白酶抑制剂
- A3261 Boceprevir中文名: 博赛泼维Summary: HCV蛋白酶抑制剂
- A3257 BMS-790052 dihydrochloride中文名: 达卡他韦二盐酸盐Summary: HCV NS5A抑制剂
- A3217 BalapiravirSummary: 聚合酶抑制剂,抗HCV
- A3195 Asunaprevir (BMS-650032)2 Citation中文名: 阿那匹韦Summary: NS3蛋白酶抑制剂