Cathepsin
Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.
- C5038 2-cyano-Pyrimidine中文名: 2-氰基嘧啶Summary: 组织蛋白酶K抑制剂
- A2487 Odanacatib (MK-0822)中文名: 奥当卡替Target: CathepsinsSummary: 组织蛋白酶K抑制剂
- A8239 CA-074 Me7 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4424 SID 26681509Target: CathepsinsSummary: 人组织蛋白酶L抑制剂
- A4412 MDL 28170Target: Cathepsins|CalpainsSummary: Calpain和cathepsin B抑制剂
- A4422 L 006235Summary: 组织蛋白酶K抑制剂
- A3284 Cathepsin S inhibitor1 CitationTarget: CathepsinsSummary: 抑制MHCII抗原呈递
- A8162 E-64-c中文名: 阿洛司他丁酸Target: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A1903 E 64d4 Citation中文名: 阿洛司他丁Summary: 半胱氨酸蛋白酶抑制剂