Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- A1902 Z-VAD-FMK102 CitationTarget: CaspasesSummary: Pan-Caspase抑制剂。
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- B3233 Z-LEHD-FMK8 CitationTarget: CaspasesSummary: 不可逆的Caspase-9抑制剂
- B3232 Z-IETD-FMK12 CitationTarget: CaspasesSummary: Caspase-8抑制剂
- A9901 Caspase Inhibitor Set ISummary: Caspase Inhibitors
- A8321 Cisplatin5 Citation中文名: 顺铂Summary: 化疗药物,抑制DNA合成
- A8238 VX-7651 Citation中文名: 贝纳卡森Target: CaspasesSummary: 有效的Caspase-1选择性抑制剂
- A4418 Ac-IEPD-AFCSummary: 丝氨酸蛋白酶granzyme B的识别基序
- A4420 PETCMSummary: Caspase-3激活剂
- A4417 IvachtinSummary: Caspase-3抑制剂