MAPK Signaling
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
- B8535 SKF86002Summary: 一种具有口服活性的 p38 MAPK 抑制剂
- B8501 GW284543Summary: MEK5选择性抑制剂
- C5850 SD 169Summary: MAP激酶p38α和p38β的选择性ATP竞争性抑制剂
- C5489 8-CPT-Cyclic AMP (sodium salt)Summary: 环AMP和环GMP依赖性蛋白激酶(PKA和PKG)的亲脂性激活剂
- C5316 RWJ 67657Summary: MAP激酶p38α和p38β的口服活性抑制剂
- C5545 MK2 Inhibitor IVTarget: MK2Summary: 高选择性、非ATP竞争性MK2抑制剂
- B7850 BMS-582949 hydrochlorideSummary: p38 MAPK抑制剂
- C4949 SB 202474Summary: 研究p38抑制的阴性对照
- C5106 LL-Z 1640-4Summary: 信号特异性JNK/p38通路和TAK 1抑制剂
- C4683 H-8 (hydrochloride)Summary: PKA和PKG的有效抑制剂