JAK/STAT Signaling
The JAK (Janus kinase) / STAT (signal transducer and activator of transcription) signaling pathway transduce signals that are essential for development, cellular differentiation and homeostasis. This pathway plays a critical role in cytokine receptor systems, regulating growth, survival and pathogen resistance. JAK is a family of non-receptor protein tyrosine kinases, consisting of JAK1, JAK2, JAK3 and TYK2 (Tyrosine Kinase-2). STATs are transcription factors that activated following recruitment to an activated receptor complex, seven STAT proteins have been identified: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.
Various ligands including cytokines (e.g. interferons and interleukins), hormones (e.g. erythropoietin and growth hormone) and their cell surface receptors activate JAK proteins, which autophosphorylate, and then phosphorylate the receptor. Subsequently, JAKs phosphorylate a specific tyrosine residue on the STAT protein, promoting dimerization via SH2 domains. The activated STATs form homo-/heterodimers and translocate to the nucleus to trigger target gene transcription. In addition, suppressors of cytokine signaling (SOCS) family inhibit receptor signaling via homologous or heterologous feedback regulation. Dysregulation in JAK/STAT signaling is associated with diseases such as atherosclerosis, immunodeficiencies and cancer.
- B8534 BP-1-102Summary: 一种口服的、有效的和特异的STAT3抑制剂
- B8518 Tyrphostin AG30 (AG30)Summary: 有效和选择性的EGFR酪氨酸激酶抑制剂
- C4650 GaliellalactoneSummary: 抑制IL-6介导的JAK/STAT信号转导
- C4533 RO8191Summary: IFN-α受体2激动剂
- C4105 STAT5 InhibitorSummary: STAT5抑制剂
- C3975 5,15-DPPSummary: STAT3抑制剂
- B7802 APTSTAT3-9RSummary: STAT3抑制剂
- B6175 STA-21Summary: STAT3抑制剂
- B6115 RG 13022Summary: EGFR酪氨酸激酶抑制剂
- B5999 FLLL32Summary: STAT3抑制剂