PARP
Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
- C4310 4-amino-1,8-NaphthalimideSummary: PARP抑制剂
- B6152 Benzamide中文名: 苯甲酰胺Summary: 聚(ADP-核糖)合成酶抑制剂
- B6150 Picolinamide中文名: 吡啶酰胺Summary: 聚(ADP-核糖)合成酶抑制剂
- B6086 BGP-15Summary: PARP抑制剂
- B1164 MK-4827 tosylate中文名: 尼拉帕尼甲苯磺酸盐Summary: PARP1/PARP2抑制剂
- B1163 MK-4827 hydrochlorideSummary: PARP1/PARP2抑制剂
- A8808 ME0328Target: PARPSummary: PARP抑制剂
- A8601 Tankyrase Inhibitors (TNKS) 49Target: TankyrasesSummary: 端锚聚合酶抑制剂
- A8600 Tankyrase Inhibitors (TNKS) 22Summary: 端锚聚合酶抑制剂
- A1877 XAV-9391 CitationTarget: TNKSSummary: Tankyrase 1/2抑制剂