Aurora Kinase
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
- A8807 MK-8745Target: Aurora KinasesSummary: Aurora A的强效选择性抑制剂。
- A4489 TC-A 2317 hydrochlorideTarget: Aurora KinasesSummary: Aurora kinase A抑制剂
- A4488 Anacardic acid中文名: 漆树酸Target: Histone Acetyltransferases (HATs)Summary: HAT抑制剂
- A3939 XL228Summary: IGF1R/AURORA/FGFR1-3/ABL/SRC家族激酶抑制剂
- A3804 SCH-1473759Summary: Aurora A/B抑制剂
- A3760 Reversine中文名: 逆转素Target: Aurora KinasesSummary: Aurora激酶抑制剂
- A3214 AZD11521 CitationTarget: Aurora KinasesSummary: Aurora B激酶抑制剂
- A4128 PF-03814735Target: Aurora KinasesSummary: Aurora A/B抑制剂
- A4127 GSK1070916Target: Aurora KinasesSummary: Aurora B/C抑制剂
- A4126 Aurora A Inhibitor I中文名: 极光A抑制剂ITarget: Aurora KinasesSummary: Aurora A抑制剂