p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- C5104 p-nitro-Cyclic Pifithrin-αSummary: p53的失活剂
- C4840 GN25Summary: p53-Snail结合抑制剂
- C4483 COTI-2Summary: 激活突变体形式的p53
- C3846 p-nitro-Pifithrin-α1 CitationSummary: p53的失活剂
- C3192 CBL0137 (hydrochloride)Summary: 激活p53并抑制NF-κB
- C3171 CBL0137Summary: 激活p53并抑制NF-κB
- B6198 ReACp53Summary: 抑制p53淀粉样蛋白形成
- B6190 NSC348884Summary: 核磷蛋白抑制剂
- B6045 NSC59984Summary: 恢复p53信号通路
- A8724 ONC201Summary: 激活p53非依赖性细胞凋亡