Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- A1902 Z-VAD-FMK102 CitationTarget: CaspasesSummary: Pan-Caspase抑制剂。
- C5667 Se-AspirinSummary: 非甾体抗炎药
- C4981 Z-Asp-CH2-DCBSummary: caspase抑制剂
- C5528 Ac-DEVD-CMKSummary: 细胞可渗透和不可逆的caspase抑制剂
- C5524 Ac-DEVD-AFCSummary: 活性caspase-3的荧光底物
- C4468 NS3694Summary: 抑制凋亡体形成和caspase激活
- A8955 Z-YVAD-FMK7 CitationTarget: CaspasesSummary: Caspase-1抑制剂
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A1919 Emricasan中文名: 恩利卡生Summary: 有效的不可逆pan-caspase抑制剂
- B3233 Z-LEHD-FMK8 CitationTarget: CaspasesSummary: 不可逆的Caspase-9抑制剂