Rhosin hydrochloride
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
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Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rhosin hydrochloride是一种有效和特异性的RhoA subfamily Rho GTPases抑制剂(Kd = 0.4μM)。Rho family GTPases是关键的细胞内信号分子,可调节细胞骨架组织、基因表达、细胞周期进程、细胞运动和其他细胞过程。Rhosin在体外和细胞内,能特异性抑制RhoA的GEF激活,并能有效抑制乳腺癌细胞的增殖和侵袭,还能诱导PC12细胞中的神经轴突生长。在体内,Rhosin被用来抑制慢性社交挫败应激后的RhoA活性。对D1 MSNs (中型多棘神经元)进行全细胞电生理记录,以评估Rhosin治疗对应激小鼠的突触和内在后果, 数据表明,抑制RhoA可防止D1-MSNs的过度兴奋性和社交挫败应激导致的D1-MSN兴奋性输入减少。Rhosin能增强与D1-MSN兴奋性相关的脊柱密度,而不影响整体树突分支。
1. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710.
2. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.
3. Francis TC, et al. The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability. Biol Psychiatry. 2019;85(12):1001-1010.
Storage | Store at -20°C |
M.Wt | 394.86 |
Cas No. | 1281870-42-5 |
Formula | C20H19ClN6O |
Solubility | ≥39.7 mg/mL in DMSO |
Chemical Name | (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride |
SDF | Download SDF |
Canonical SMILES | O=C([C@@H](CC1=CNC2=C1C=CC=C2)N)N/N=C/C3=CC=C4N=CC=NC4=C3.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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