PQ 401
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PQ401是一种新型有效的IGF-IR抑制剂,IC50值为12 μM[1]。
在人MCF-7细胞中,PQ401抑制IGF-IR的自磷酸化,IC50值为12 μM,抑制分离的IGF-IR激酶结构域的自磷酸化,IC50值小于1 μM。此外,10 μM 的PQ401可抑制血清培养的乳腺癌细胞生长。PQ401可通过Akt抗凋亡途径,减少IGF-I介导的信号。15 μM的PQ401处理二十四小时可减少caspase介导的细胞凋亡[1]。在小三叉神经节神经元中,PQ401可阻断IGF-1诱导的A型K(+)电流(IA),其与电压依赖性失活的超极化位移有关[2]。
在体内,一周三次的PQ401治疗可降低植入小鼠的MCNeuA细胞的生长速率[1]。
参考文献:
[1]. Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86.
[2]. Wang H, Qin J, Gong S, Feng B, Zhang Y, Tao J. Insulin-like growth factor-1 receptor-mediated inhibition of A-type K(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of Akt. Endocrinology. 2014 Jan;155(1):168-79.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 341.79 |
Cas No. | 196868-63-0 |
Formula | C18H16ClN3O2 |
Solubility | insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with ultrasonic |
Chemical Name | 1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea |
SDF | Download SDF |
Canonical SMILES | CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | PQ 401是一种细胞渗透性的胰岛素样生长因子受体(IGF1R)抑制剂,IC50值为12 μM。 | |||||
靶点 | IGF1R | |||||
IC50 | 12 μM |
化学结构
![PQ 401](http://www.apexbt.com//media/diy/images/struct/A2033.png)