Phytol
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Phytol is an activator of retinoid X receptors (RXRs) [1,2].
The retinoid X receptors (RXRs) are nuclear receptors activated by 9-cis retinoic acid. RXRs are members of the steroid/thyroid hormone receptor superfamily of DNA binding nuclear hormone receptors. The RXRs are cofactors required for transcription activated by some other members of the steroid/thyroid hormone receptor superfamily, including the all-truns retinoic acid, vitamin D, thyroid hormone, and peroxisome proliferator-activated receptors. Some RXR null mutations in mice show phenotypic effects similar to vitamin A deficiency. Retinoids, metabolites of vitamin A, act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The retinoids has been successfully used in treating skin diseases and some forms of cancer [3].
Phytol activated retinoid X receptors (RXRs) with the Ki range from 2.3 to 67.2 μM [2]. Phytol was a diterpene alcohol obtained from the degradation of chlorophyll. Phytol has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol converted to phytanic acid [2]. Phytol was readily absorbed in the small intestine and converted to phytanic acid in human. In a number of metabolic disorders, Phytanic acid accumulated to toxic levels[2]. The conversion of phytol to phytanic acid was regulated via the activation of peroxisome proliferator-activated receptor α (PPARα). Phytol showed sedative and anxiolytic effects through interaction with the GABAA receptor, and it was explored as an antischistosomal agent in a mouse model of schistosomiasis [4].
References:
[1] Kitareewan S, Burka L T, Tomer K B, et al. Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR[J]. Molecular Biology of the Cell, 1996, 7(8): 1153-1166.
[2] Gloerich J, van den Brink D M, Ruiter J P N, et al. Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation[J]. Journal of lipid research, 2007, 48(1): 77-85.
[3] Rowe A. Retinoid X receptors[J]. The international journal of biochemistry & cell biology, 1997, 29(2): 275-278.
[4] Costa J P, de Oliveira G A L, de Almeida A A C, et al. Anxiolytic-like effects of phytol: possible involvement of GABAergic transmission[J]. Brain research, 2014, 1547: 34-42.
Physical Appearance | A neat oil |
Storage | Store at -20°C |
M.Wt | 296.5 |
Cas No. | 150-86-7 |
Formula | C20H40O |
Synonyms | trans-Phytol |
Solubility | insoluble in H2O; ≥46.1 mg/mL in EtOH; ≥57.4 mg/mL in DMSO |
Chemical Name | 3,7R,11R,15-tetramethyl-2E-hexadecen-1-ol |
SDF | Download SDF |
Canonical SMILES | CC(CCC[C@@H](C)CCC[C@@H](C)CCC/C(C)=C/CO)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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