Oleoyl Ethyl Amide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity [1].
Fatty acid amide hydrolase (FAAH) is an integral membrane hydrolase and a member of the serine hydrolase family of enzymes. In vitro, FAAH has esterase and amidase activity. In vivo, FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs).
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor. In rat brain homogenates, Oleoyl Ethyl Amide inhibited FAAH activity with IC50 value of 5.25 nM, but did not bind to CB1 or CB2 receptors, or inhibit acidic PEAase. Oleoyl Ethyl Amide is a potent and selective FAAH inhibitor with potential analgesic and anxiolytic activity [1].
In Sprague-Dawley rats, subcutaneous injections of OEtA (0.3 mg/kg) for 2 weeks increased values of micturition intervals (MI) and volumes (MV), bladder capacity (BC), threshold pressure, and flow pressure. OEtA altered sensory urodynamic parameters and reduced bladder overactivity [2].
References:
[1]. Vandevoorde, S.,Lavand'homme, P.,Fowler, C.J., et al. Oleoylethylamide, an analgesic FAAH inhibitor which modulates endogenous anandamide, oleoylethanolamide, and 2-arachidonoylglycerol levels in the brain. 14th Annual Symposium on the Cannabinoids 15-15 (2004).
[2]. Gandaglia G, Strittmatter F, La Croce G, et al. The fatty acid amide hydrolase inhibitor oleoyl ethyl amide counteracts bladder overactivity in female rats. Neurourol Urodyn. 2014 Nov;33(8):1251-8.
Physical Appearance | A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
Storage | Store at -20°C |
M.Wt | 309.5 |
Cas No. | 85075-82-7 |
Formula | C20H39NO |
Synonyms | OEtA,N-Ethyloleamide |
Solubility | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
Chemical Name | N-ethyl-9Z-octadecenamide |
SDF | Download SDF |
Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)NCC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |