Necroptosis Inducer Kit
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
细胞程序性坏死或坏死性凋亡(Necroptosis)是一种新型的细胞死亡方式。当凋亡条件缺乏时(主要是caspase酶被抑制时),特别是含有caspase抑制剂的情况下,肿瘤坏死因子受体家族(TNF-α受体)以及Toll-like受体家族启动,然后激活两个蛋白激酶RIP1和RIP3,最终引起细胞坏死。程序性坏死是一种重要的细胞死亡机制,在肿瘤、神经性退行疾病和炎症中发挥重要作用。
细胞程序性坏死诱导试剂盒(Necroptosis Inducer Kit)提供一种由重组人TNF-α、SM-164和Z-VAD-FMK(简称TSZ)按一定比例混合而成的试剂,可以有效的诱导细胞程序性坏死。其中重组人TNF-α是一种促炎细胞因子,具有多种功能;SM-164是Smac的二价模拟物,可以诱导TNF-α依赖性的凋亡;Z-VAD-FMK是一种可以穿透细胞膜的泛Caspase抑制剂。本试剂盒中的试剂为即用型溶液,可以直接用于诱导细胞程序性坏死,方便快捷。对于6孔板,每孔使用2 mL细胞培养基,本试剂盒可用于诱导100或500个样本的程序性坏死;对于96孔板,每孔使用200 μL细胞培养基,本试剂盒可用于诱导1000或5000个样品的程序性坏死。
Components | K2712-100 T | K2712-500 T |
Necroptosis Inducer Reagent (1000x) | 200 μL | 1 mL |
Store the reagent at -20°C, stable for 1 year. |