N-Benzylpalmitamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH) [1].
The fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH is involved in degrading the fatty acid amide family of endogenous signaling lipids, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to is a member of amidase signature (AS) family. The FAAH integrates into cell membranes and terminates fatty acid amide signaling in vivo [2]. Genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence [3].
N-Benzylpalmitamide was a long-chain fatty acid amide isolated from the maca (L. meyenii) plant and was structurally related to cannabinoids. N-Benzylpalmitamide was a moderate inhibitor of FAAH and inhibited 44% activity of FAAH at 500 μM [1].
References:
[1] Wu H, Kelley C J, Pino-Figueroa A, et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5188-5197.
[2] Deutsch D G, Ueda N, Yamamoto S. The fatty acid amide hydrolase (FAAH)[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002, 66(2): 201-210.
[3] Sipe J C, Chiang K, Gerber A L, et al. A missense mutation in human fatty acid amide hydrolase associated with problem drug use[J]. Proceedings of the National Academy of Sciences, 2002, 99(12): 8394-8399.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 345.6 |
Cas No. | 74058-71-2 |
Formula | C23H39NO |
Synonyms | N-Benzylhexadecanamide |
Solubility | ≤2mg/ml in organic solvent ethanol |
Chemical Name | N-(phenylmethyl)-hexadecanamide |
SDF | Download SDF |
Canonical SMILES | O=C(CCCCCCCCCCCCCCC)NCC1=CC=CC=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |