MN 64
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MN-64是一类黄酮,用作一种强效的和选择性的tankyrase抑制剂(作用于TNKS1和TNKS2的IC50分别为6和72 nM).[1]
Tankytase (TNKS)是聚ADP核糖聚合酶(PARPs)的成员之一.两个相关的同系物TNKS1和TNKS2大多位于核孔\细胞质\有丝分裂中心体和高尔基体.它们参与细胞功能,如人类细胞中调节细胞增殖和促进端粒延伸.[1]
在筛选黄酮TNKS抑制剂的实验中,发现200 nM 的MN-64去除STF萤光素酶活性并强效抑制TNKS1,IC50为6 nM.MN-64还选择性地抑制TNKS1和TNKS2而不影响任何其他PARPs.此外,MN-64比其他TNKS抑制剂如XAV939更具选择性.[1]
参考文献:
1. Narwal M, Koivunen J, Haikarainen T et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 264.32 |
Cas No. | 92831-11-3 |
Formula | C18H16O2 |
Solubility | insoluble in H2O; ≥11.65 mg/mL in DMSO; ≥25.9 mg/mL in EtOH |
Chemical Name | 2-(4-isopropylphenyl)-4H-chromen-4-one |
SDF | Download SDF |
Canonical SMILES | CC(C1=CC=C(C2=CC(C3=CC=CC=C3O2)=O)C=C1)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
![MN 64](http://www.apexbt.com//media/diy/images/struct/B5983.png)