ML161
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ML161是PAR1的选择性抑制剂,IC50值为0.26 μM。
蛋白酶激活受体-1(PAR-1)是特异的G蛋白偶联受体,属于蛋白酶活化受体家族,其活化诱导了一系列下游信号事件,导致多种与肿瘤进展相关的细胞应答[1] 。
ML161是一种强效的PAR1抑制剂,与已知的ALK抑制剂crizotinib具有不同的选择性。在人血小板中,通过检测P-选择素表达发现,ML161以剂量依赖性方式抑制凝血酶诱导的血小板的活化[1]。在颗粒分泌中,ML161以剂量依赖的方式抑制P-选择素的表达,EC50值为0.3 μM,也抑制SFLLRN诱导的血栓形成[2]。
参考文献:
[1]. Dockendorff, C., et al., Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. ACS Med Chem Lett, 2012. 3(3): p. 232-237.
[2]. VerPlank, L., et al., Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3, in Probe Reports from the NIH Molecular Libraries Program. 2010, National Center for Biotechnology Information (US): Bethesda (MD).
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 361.23 |
Cas No. | 423735-93-7 |
Formula | C17H17BrN2O2 |
Solubility | insoluble in H2O; ≥16.4 mg/mL in DMSO; ≥46.9 mg/mL in EtOH with ultrasonic |
Chemical Name | 2-bromo-N-[3-(butanoylamino)phenyl]benzamide |
SDF | Download SDF |
Canonical SMILES | CCCC(=O)NC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2Br |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | ML-161是PAR1的变构抑制剂,IC50值为0.26 μM。 | |||||
靶点 | PAR1 | |||||
IC50 | 0.26 μM |
质量控制和MSDS
- 批次:
化学结构
![ML161](http://www.apexbt.com/media/diy/images/struct/A8229.png)