LH846
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
LH846是酪蛋白激酶抑制剂,对CKIδ\CKIα和CKIε的IC50值分别为290 nM\2.5 μM和1.3 μM.
LH846作为一种酪蛋白激酶的小分子抑制剂,被研发用于治疗由昼夜节律紊乱引发的相关疾病.LH846是从基于人U2OS细胞的试验中被筛选出来的,在8 μM的浓度下,能够影响昼夜节律并延长周期(10小时).LH846可以抑制CKIδ\CKIα和CKIε活性,其IC50值分别为290 nM\2.5 μM和1.3 μM.LH846的特异性靶点是CKIδ.在约50种激酶中,LH846有效抑制CKIδ,对CKIα和ROCK2抑制作用相对较弱.CK2对LH846不敏感[1].
参考文献:
[1] Lee J W, Hirota T, Peters E C, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie, 2011, 123(45): 10796-10799.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 316.81 |
Cas No. | 639052-78-1 |
Formula | C16H13ClN2OS |
Solubility | Soluble in DMSO |
Chemical Name | (Z)-N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetimidic acid |
SDF | Download SDF |
Canonical SMILES | CC1=CC(S2)=C(N=C2/N=C(O)/CC3=CC=CC=C3)C=C1Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
化学结构
![LH846](http://www.apexbt.com//media/diy/images/struct/B1237.png)