KU14R
Catalog No.
A3534
I(3)-R拮抗剂
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A new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.
Physical Appearance | White solid |
Storage | Store at -20°C |
M.Wt | 214.26 |
Cas No. | 189224-48-4 |
Formula | C13H14N2O |
Synonyms | KU-14R;KU 14R |
Solubility | Soluble in DMSO |
Chemical Name | 2-(2-ethyl-2,3-dihydrobenzofuran-2-yl)-1H-imidazole |
SDF | Download SDF |
Canonical SMILES | CCC1(C2=NC=CN2)CC3=CC=CC=C3O1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |