IRAK inhibitor 4
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
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Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
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Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
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Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IRAK inhibitor 4是白细胞介素-1受体相关激酶(IRAK,interleukin-1 receptor-associated kinase)抑制剂[1]。
IRAK-4属于白细胞介素-1受体相关激酶家族,是信号传导途径中的关键组分。IRAK-4介导白细胞介素-1受体(IL-1R)、白细胞介素-18受体(IL-18R)和Toll样受体(TLR)下游的信号转导。 IRAK-4的抑制可以调节其功能,从而下调炎症反应。IRAK inhibitor 4是一种吲唑(indazole)类抑制剂。作为IRAK-4的抑制剂,咪唑并[1,2-b]哒嗪(imidazo[1,2-b]pyridazines)和吲唑(indazole)被用于治疗一些炎症、细胞增殖性和免疫相关疾病[1]。
参考文献:
[1] Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh. IRAK-4 Inhibitors for Inflammation. Current Topics in Medicinal Chemistry. 2009, 9: 724-737.
Storage | Store at -20°C |
M.Wt | 620.66 |
Cas No. | 1012104-68-5 |
Formula | C33H35F3N6O3 |
Solubility | Soluble in DMSO |
Chemical Name | 1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide |
SDF | Download SDF |
Canonical SMILES | CC(C)CCNC(=O)C1=CC2=C(C=C1)N(C(=N2)NC3=NNC4=C3C=C(C=C4)C5=CC=CC=C5OC(F)(F)F)C6CCC(CC6)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | IRAK inhibitor 4是白细胞介素-1受体相关激酶(IRAK,interleukin-1 receptor-associated kinase)抑制剂。 | |||||
靶点 | IRAK | |||||
IC50 |
化学结构
![IRAK inhibitor 4](http://www.apexbt.com//media/diy/images/struct/A3503.png)