Escitalopram Oxalate
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
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Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
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Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
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Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Escitalopram Oxalate(Lexapro\Cipralex)是一种血清素(5-HT)再吸收的选择性抑制剂(SSRI),对[3H]-5-HT吸收的Ki值为6.6 nM[1].
Escitalopram Oxalate是西酞普兰的S-(+)-对映体,在表达人类血清素转运子(5-HTT)的COS-1细胞中可抑制[3H]-5-HT吸收和[125I]-RTI-55结合,Ki值分别为6.6±1.4 nM和3.9±2.2 nM.此外,Escitalopram Oxalate可在体外抑制3H标记的单胺在大鼠脑突触体的积累,对[3H]-5-HT\[3H]-I-NA和[3H]-DA的IC50值分别为2.1±0.75 nM\ 2500±202 nM和40000±15500 nM.除此之外,Escitalopram Oxalate对大鼠组胺H1受体和大鼠σ1位点具有体外亲和性,Ki值分别为1500±780 nM和100±71 nM[1].
参考文献:
[1] Sánchez C1, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 2003 Jun;167(4):353-62. Epub 2003 Apr 26.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 414.43 |
Cas No. | 219861-08-2 |
Formula | C22H23FN2O5 |
Solubility | ≥10.6 mg/mL in H2O; ≥2.31 mg/mL in EtOH with ultrasonic; ≥41.45 mg/mL in DMSO |
Chemical Name | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid |
SDF | Download SDF |
Canonical SMILES | CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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