CTS-1027
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CTS-1027是MMP的选择性抑制剂,对MMP-2和MMP-13的IC50值分别为0.4 nM和0.6 nM[1]。
MMPs(基质金属蛋白酶)是锌依赖性内肽酶,在降解各种胞外基质蛋白中发挥重要作用。众所周知,MMPs参与细胞膜受体的裂解、凋亡配体的释放和趋化因子/细胞因子的失活,MMPs还参与细胞的增殖、迁移、分化、血管生成、细胞凋亡和宿主防御[2] [3]。
在C57 / BL6小鼠模型中,胆管结扎(BDL)14天后,灌胃给予CTS-1027可减少肝细胞和胆管梗塞,这两者是肝损伤的组织学指标,同时活化星状细胞,降低肝纤维化[4]。
参考文献:
[1].Barta, T.E., et al., Selective, orally active MMP inhibitors with an aryl backbone. Bioorg Med Chem Lett, 2001. 11(18): p. 2481-3.
[2].Toth, M., A. Sohail, and R. Fridman, Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography. Methods Mol Biol, 2012. 878: p. 121-35.
[3].Roomi, M.W., et al., Patterns of MMP-2 and MMP-9 expression in human cancer cell lines. Oncol Rep, 2009. 21(5): p. 1323-33.
[4].Kahraman, A., et al., Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouse. Hepatol Res, 2009. 39(8): p. 805-13
.Storage | Store at -20°C |
M.Wt | 425.88 |
Cas No. | 193022-04-7 |
Formula | C19H20ClNO6S |
Synonyms | RS 130830;Ro 1130830;CTS1027;CTS 1027;RS130830;Ro1130830;RS-130830;Ro-1130830 |
Solubility | Soluble in DMSO |
Chemical Name | 4-[[4-(4-chlorophenoxy)phenyl]sulfonylmethyl]-N-hydroxyoxane-4-carboxamide |
SDF | Download SDF |
Canonical SMILES | C1COCCC1(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C(=O)NO |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | CTS-1027是金属蛋白酶(MMPs)的口服可利用的小分子抑制剂,对MMP-2、MMP-13和MMP-1的IC50值分别为0.4 nM、0.6 nM和800 nM。 | |||||
靶点 | MMP-2 | MMP-13 | MMP-1 | |||
IC50 | 0.4 nM | 0.6 nM | 800 nM |
化学结构
![CTS-1027](http://www.apexbt.com//media/diy/images/struct/A3334.png)
相关生物数据
![CTS-1027 CTS-1027](http://www.apexbt.com/media/diy/images/wb/A3334_1.jpg)