Calcitriol
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Calcitriol是维生素D的一种形式,可转变成比其他形式的维生素D更有效和速效的代谢产物[1]。
Calcitriol通过调控细胞免疫系统的分化、生长和功能,在矿物质和骨骼稳态方面扮演重要角色。体外研究显示,calcitriol在人外周血细胞(PBMC)中可剂量依赖地抑制LPS诱发的肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)的产生。此外,在体内实验中,calcitriol也可显著地降低TNF-α和IL-1β的基底透析增加。除此之外,calcitriol也被报道可通过对钙和PTH代谢的直接作用,调节细胞因子的生成[2]。
参考文献:
[1] Holick MF, Schnoes HK, DeLuca HF. Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A. 1971 Apr;68(4):803-4.
[2] Panichi V1, De Pietro S, Andreini B, Bianchi AM, Migliori M, Taccola D, Giovannini L, Tetta C, Palla R. Calcitriol modulates in vivo and in vitro cytokine production: a role for intracellular calcium. Kidney Int. 1998 Nov;54(5):1463-9.
- 1. Jie Zhou, et al. "Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation." Cell Death Dis. 2024 Feb 12;15(2):136. PMID: 38346941
- 2. Kumar A, Wilderman PR, et al. "Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1." Biochemistry. 2020;59(15):1537-1548. PMID: 32259445
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 416.64 |
Cas No. | 32222-06-3 |
Formula | C27H44O3 |
Solubility | insoluble in H2O; ≥20.83 mg/mL in DMSO; ≥43.5 mg/mL in EtOH |
Chemical Name | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
SDF | Download SDF |
Canonical SMILES | CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验[1]: | |
细胞系 |
基底细胞癌(BBC)细胞系ASZ001 |
溶解方法 |
在DMSO中的溶解度大于20.8mg/mL。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
10 nM,48 h |
应用 |
在BCC ASZ001细胞中,calcitriol显著抑制Hh信号通路,激活Vdr信号通路。Calcitriol抑制细胞增殖,但是caspase 3/7的活性没有变化,所以其对凋亡没有影响。 |
临床实验[2]: | |
临床样本 |
11-35岁的近期发病1型糖尿病病人 |
剂量 |
每天0.25 μg,持续2年 |
应用 |
在6,12和24个月,calcitriol组和安慰剂组的A1C,C肽和胰岛素需求值没有区别。这些结果表明,所使用剂量的calcitriol不能保护具有高C肽的近期发病1型糖尿病病人的β细胞功能。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同。这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Uhmann A, Niemann H, Lammering B, et al. Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation[J]. Molecular cancer therapeutics, 2011, 10(11): 2179-2188. [2]. Bizzarri C, Pitocco D, Napoli N, et al. No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes[J]. Diabetes care, 2010, 33(9): 1962-1963. |
质量控制和MSDS
- 批次:
化学结构
![Calcitriol](http://www.apexbt.com//media/diy/images/struct/B2141.png)
相关生物数据
![Calcitriol Calcitriol](http://www.apexbt.com/media/diy/images/wb/B2141_1.jpg)