BX-912
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BX-912是3-磷酸肌醇依赖性激酶(3-phosphoinositide-dependent kinase 1,PDK1)的一种有效的、选择性抑制剂,IC50值26 nM[1]。BX-912对PDK1的选择性是PKA的9倍,是PKC的105倍[1]。
已显示BX-912抑制MDA-468细胞(一种表达高水平激活的Akt的乳腺癌肿瘤细胞)的生长,提高Caspase-3/7的活性。然而BX-912不影响正常的原始PrECs和原始HMECs细胞中的Caspase-3/7活性。此外,已证实BX-912能诱导MDA-468细胞的细胞周期停止在G2/M期[1]。
参考文献:
[1] Feldman RI1,Wu JM,Polokoff MA,Kochanny MJ,Dinter H,Zhu D,Biroc SL,Alicke B,Bryant J,Yuan S,Buckman BO,Lentz D,Ferrer M,Whitlow M,Adler M,Finster S,Chang Z,Arnaiz DO. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem.2005 May 20;280(20):19867-74. Epub 2005 Mar 16.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 471.35 |
Cas No. | 702674-56-4 |
Formula | C20H23BrN8O |
Solubility | ≥23.55 mg/mL in DMSO; insoluble in H2O; ≥10.25 mg/mL in EtOH |
Chemical Name | N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide |
SDF | Download SDF |
Canonical SMILES | C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | BX-912一个有效的、ATP竞争性的PDK1抑制剂,IC50值26 nM。 | |||||
靶点 | PDK-1 | |||||
IC50 | 26 nM |
质量控制和MSDS
- 批次:
化学结构
![BX-912](http://www.apexbt.com//media/diy/images/struct/A2806.png)