BMY 45778
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BMY 45778是一种前列腺素受体的部分激动剂[1].
前列腺素受体(IP1)是一种前列腺素的G蛋白偶联受体.前列腺素抑制血小板聚集,并通过结合该受体引起强力的血管扩张.
BMY 45778是一种前列腺素受体的部分激动剂.BMY 45778抑制血小板聚集,在人\兔和大鼠中的IC50值分别为35 nM\136 nM和1.3 μM.在人类血小板膜中,BMY 45778激活腺苷酸环化酶,ED50值为6-10 nM,并刺激GTP酶.此外,BMY 45778完全抑制伊洛前列素结合至血小板膜,IC50值为7 nM.BMY 45778抑制伊洛前列素刺激GTP酶,这表明BMY 45778是一种前列腺素受体的部分激动剂.在完整血小板中,BMY 45778提高cAMP水平并活化cAMP依赖性蛋白激酶[1].BMY 45778(1-10 μM)抑制N-甲酰基-甲硫氨酰-亮氨酰苯丙氨酸诱导的大鼠嗜中性粒细胞的聚集,IC50值为20 nM,并抑制10-20％的大鼠结肠自发活动.此外,BMY 45778(10 μM)抑制cicaprost对大鼠结肠的抑制作用[2].
参考文献：
[1]. Seiler SM, Brassard CL, Federici ME, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins, 1997, 53(1): 21-35.
[2]. Wise H, Qian YM, Jones RL. A study of prostacyclin mimetics distinguishes neuronal from neutrophil IP receptors. Eur J Pharmacol, 1995, 278(3): 265-269.
| Physical Appearance | Off-white solid |
| Storage | Store at 4°C |
| M.Wt | 438.44 |
| Cas No. | 152575-66-1 |
| Formula | C26H18N2O5 |
| Solubility | ≥67.6 mg/mL in DMSO |
| Chemical Name | 2-(3-(4,5-diphenyl-[2,4'-bioxazol]-5'-yl)phenoxy)acetic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(COC1=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=CC=C1)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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化学结构
