BGP-15
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ki =57 μM
BGP-15是一种PARP抑制剂。
作为聚ADP核糖聚合酶(PARP)的一组药理学抑制剂,PARP抑制剂被认为是中风和心肌梗塞的一种潜在治疗策略。
体外:之前的研究表明,200 μM的BGP-15可以防止imatinib诱导的氧化损伤,减少高能磷酸盐的消耗,通过阻止p38 MAP激酶和JNK活化来改变imatinib的信号传导效应,还诱导Akt和GSK-3β磷酸化[1]。
体内:体内研究表明,BGP-15改善心脏功能并减少HF和AF两种小鼠模型中的心律失常发作。在这些模型中,BGP-15与IGF1R的磷酸化增加相关。此外,小鼠的心脏特异性IGF1R转基因过表达概括了BGP-15引起的保护。提出者进一步证实,BGP-15对IGF1R的作用可以提供独立于磷酸肌醇3-激酶-Akt和热休克蛋白70的保护[2]。
临床试验:已经安排了BGP-15在2型糖尿病患者中安全性和有效性的临床试验,然而,由于资金支持撤回,本研究现已终止。 (https://clinicaltrials.gov/ct2/show/NCT01069965 term = BGP-15&rank = 1)
参考文献:
[1] Sarszegi Z,Bognar E,Gaszner B,Kónyi A,Gallyas F Jr,Sumegi B,Berente Z. BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem.2012 Jun;365(1-2):129-37.
[2] Sapra G,Tham YK,Cemerlang N,et al. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun.2014 Dec 9;5:5705.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 351.27 |
Cas No. | 66611-37-8 |
Formula | C14H24Cl2N4O2 |
Solubility | Soluble in DMSO |
Chemical Name | N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride |
SDF | Download SDF |
Canonical SMILES | N=C(NOCC(O)CN1CCCCC1)C2=CN=CC=C2.Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
化学结构
![BGP-15](http://www.apexbt.com//media/diy/images/struct/B6086.png)