BAW2881 (NVP-BAW2881)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
作用于VEGFR1-3,IC50为1.0-4.3 nM。
BAW2881(NVP-BAW2881)是一种VEGFR抑制剂。
血管内皮生长因子(VEGF)是一种强效的内皮细胞有丝分裂原,调节血液和淋巴管发育和体内平衡。VEGFR有三种主要亚型,分为VEGFR1、2和3。
体外:先前的研究表明,BAW2881在亚微摩尔IC50下可以抑制有限数量的激酶,包括c-RAF、B-RAF、RET、ABL和TIE-2。BAW2881还可以抑制配体诱导的RET、PDGFR和KIT激酶的自磷酸化。此外,低IC50值(0.12±0.06 nM)表明BAW2881显著地消除VEGF诱导的增殖[1]。
体内:在牛皮癣小鼠模型中,BAW2881能够减少皮肤中血液、淋巴管和浸润白细胞的数目,并使表皮结构正常化。BAW2881在急性炎症模型中还显示出强烈的抗炎作用。此外,用局部BAW2881预处理可以显著抑制猪和小鼠皮肤中VEGF-A诱导的血管通透性。此外,研究发现BAW2881的局部施用能够减少由UV-B照射或接触性超敏反应引起的猪皮肤炎症反应[2]。
临床试验:到目前为止,BAW2881仍处于临床前研究阶段。
参考文献:
[1] Bold G et al. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J Med Chem.2016 Jan 14;59(1):132-46.
[2] Halin C,Fahrngruber H,Meingassner JG,Bold G,Littlewood-Evans A,Stuetz A,Detmar M. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol.2008 Jul;173(1):265-77.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 424.38 |
Cas No. | 861875-60-7 |
Formula | C22H15F3N4O2 |
Solubility | ≥42.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide |
SDF | Download SDF |
Canonical SMILES | O=C(C1=C2C=CC(OC3=NC(N)=NC=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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