ALK-IN-1
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ALK-IN-1是一种新型的、合成的间变性淋巴瘤激酶(ALK)口服小分子抑制剂,IC50(最大半数抑制浓度)范围为5 nmol/l至11 nmol/l,ALK是胰岛素受体超家族的受体酪氨酸激酶。ALK-IN-1也能够抑制ALK酪氨酸激酶突变L1196M,IC50为15 nmol/l 至45 nmol/L、抑制表皮生长因子受体(EGFR)突变体T790M突变和c-ros的癌基因1(ROS1)。而且,ALK-IN-1在含野生型或突变型EML4-ALK的H3122细胞(敏感的和抗性的)和Ba / F3细胞(IC50分别为10 nM和24 nM)中也具有活性。
参考文献:
[1]Solomon B, Wilner KD, Shaw AT. Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer. Clin Pharmacol Ther. 2014 Jan;95(1):15-23. doi: 10.1038/clpt.2013.200. Epub 2013 Oct 3.
[2]Katayama R1, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, Shakespeare WC, Iafrate AJ, Engelman JA, Shaw AT. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. doi: 10.1073/pnas.1019559108. Epub 2011 Apr 18.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 529.01 |
Cas No. | 1197958-12-5 |
Formula | C26H34ClN6O2P |
Synonyms | Brigatinib analog |
Solubility | ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH |
Chemical Name | 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine |
SDF | Download SDF |
Canonical SMILES | CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | ALK-IN-1 is a potent inhibitor of ALK with IC50 of 0.62 nM. | |||||
Targets | ALK | FER | ROS/ROS1 | FLT3 | FES/FPS | |
IC50 | 0.62 nM | 1.3 nM | 1.9 nM | 2.1 nM | 3.4 nM |
化学结构
![ALK-IN-1](http://www.apexbt.com/media/diy/images/struct/A1367.png)
相关生物数据
![ALK-IN-1 ALK-IN-1](http://www.apexbt.com/media/diy/images/wb/A1367_1.jpg)