ANR 94
![mRNA synthesis](/media/diy/images/page/figure1-mrna.png)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
![Tyramine Signal Amplification (TSA)](/media/diy/images/page/figure2-01.png)
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
![screening library](/media/diy/images/page/figure3-01.png)
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
![Cell Counting Kit-8 (CCK-8)](/media/diy/images/page/CCK-8.jpg)
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
![SYBR Safe DNA Gel Stain](/media/diy/images/page/SYBR Safe DNA Gel Stain.png)
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
![Inhibitor Cocktails](/media/diy/images/page/Inhibitor Cocktails.jpg)
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
8-乙氧基-9-乙基腺嘌呤(ANR 94)在体外是一种腺苷受体拮抗剂。该物质的结构已公开[1]。ANR 94对人类腺苷A2A受体亚型具有高选择性和亲和性,并在单侧6-羟基多巴胺(6-OHDA)损伤的大鼠中具有高抗帕金森病活性[2]。ANR 94对腺苷A2A受体的Ki值为46 nM[1]。
腺苷参与运动表现的控制[1]。
在稳定转染人类重组腺苷受体的中华仓鼠卵巢(CHO)细胞中,ANR 94比ANR 82对腺苷A2A受体有更高的选择性,Ki值为46 nM [1]。ANR 94处理(0.5 mg/kg i.p. 7天)可显著防止1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的TH阳性细胞恶化(p < 0.0005)[2]。
在大鼠中,ANR 94在5 mg/kg i.p.剂量下不能改变自发运动,然而在较高的剂量(10或15 mg/kg)下,该物质可诱导运动过度。ANR 94在1 mg/kg剂量下对全身僵硬症效果较差,但在5 mg/kg下则完全有效。在重度僵住症大鼠中,在90-min的测试周期中,ANR 94在5 mg/kg i.p.剂量下可显著逆转0.2 mg/kg氟哌啶醇诱导的僵住症。从30-60 min,ANR 94效果最强。ANR 94的抗僵住症效果持续长达150 min以上。在6-OHDA损伤的大鼠中,ANR 94可显著增加l-DOPA(3 mg/kg)诱导的对侧旋转数量,这一效果可持续到120-130 min[2]。
参考文献:
[1]. Annalisa Pinna, Rosaria Volpini, Gloria Cristalli, et al. New adenosine A2A receptor antagonists: Actions on Parkinson’s disease models. European Journal of Pharmacology, 2005, 512:157-164.
[2]. Annalisa Pinna, Elisabetta Tronci, Nicoletta Schintu, et al. A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology, 2010, 58: 613-623.
Physical Appearance | Off-white solid |
Storage | Store at RT |
M.Wt | 207.23 |
Cas No. | 634924-89-3 |
Formula | C9H13N5O |
Solubility | <10.36mg/ml in DMSO; <20.72mg/ml in ethanol |
Chemical Name | 8-ethoxy-9-ethyl-9H-purin-6-amine |
SDF | Download SDF |
Canonical SMILES | NC1=C2N=C(N(CC)C2=NC=N1)OCC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
化学结构
![ANR 94](http://www.apexbt.com//media/diy/images/struct/B7540.png)