Amyloid β-Peptide (10-20) (human)

在阿尔茨海默病（AD）中，β-淀粉样蛋白(Aβ）可以引发神经退行性病变 1。在非正常生理条件下，由β淀粉样前体蛋白(β-amyloid precursor protein,APP)水解产生，是一种分解代谢副产物2。

Aβ是许多不同受体和其它分子的配体3-5，通过复杂转运通路在组织和血脑屏障中运输。Aβ响应于各种不同的环境压力，能够诱导促炎活性⁷。

可溶性β淀粉样多肽片段是明胶酶A/ IV型胶原酶/MMP-2及APP分泌酶的底物，作用于Lys16和Leu17之间，使蛋白断裂。

Figure1. Structure of Amyloid β-Peptide

参考文献：

1. Small, D.H., Mok, S.S. & Bornstein, J.C. Alzheimer’s disease and Aβ-toxicity: From top to bottom. Nature Rev. Neurosci. 2, 595–598 (2001)

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